Results 31 to 40 of about 116,983 (264)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Optimization of a reliable, fast, cheap and sensitive silver staining method to detect SSR markers in polyacrylamide gels [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2006 A reliable, fast, cheap and sensitive silver staining method to detect nucleic acids in polyacrylamide gels was developed from two standard stain procedures.
Mergeai G. +3 more
doaj
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
AN IMPROVED MODIFIED PROTOCOL FOR SILVER STAINING OF DS DNA IN AGAROSE GEL
Pakistan Armed Forces Medical Journal, 2019 Objective: Present study was aimed to develop a reproducible, cheap and sensitive method for silver staining of double stranded DNA in agarose gel. Study Design: Experimental, repeated measure design.
Nuzhat Aisha Ikram +5 more
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
DETECTION OF AVIAN ROTAVIRUS USING THE REVERSE TRANSCRIPTION (RT)-PCR AND RNA-PAGE IN DIARRHOEIC POULTRY FROM KERALA, INDIA [PDF]
Journal of Veterinary and Animal Sciences, 2016 Rotavirus is one of the most common viral causes of diarrhoea in poultry causing significant economic losses. Hence a study was undertaken to detect the presence of rotavirus in faecal samples by RT-PCR and the RNA profile of the virus was analysed by ...
B. Rinsha +4 more
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Indian Journal of Ophthalmology, 2002 The Gomoris methanamine silver impregnation technique is a highly reliable and archiveable method of detecting fungal filaments, but the staining procedure is time consuming and laborious.
Vemuganti Geeta +2 more
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