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Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications. [PDF]
Asia Pac J Clin NutrZhang Z, Li S, Sun J.
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Silymarin: not just another antioxidant
Journal of Basic and Clinical Physiology and Pharmacology, 2020Abstract Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract that has been used for many centuries to treat liver diseases. In recent years, several studies have shown that SM is not only just another antioxidant but also a multifunctional compound that exhibits several beneficial properties for use in the ...
Fernanda Caetano, Camini +1 more
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Silymarin, an inhibitor of lipoxygenase
Experientia, 1979Silybin (I), silydianin (II) and silychristin (III), the constituents of silymarin, non-competitively inhibit the lipoxygenase from soybeans (EC 1.13.11.12) in vitro.
F, Fiebrich, H, Koch
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Clinical Drug Investigation, 2002
The flavonoid silymarin and one of its structural components, silibinin, are substances with documented hepatoprotective properties. Their mechanisms of action are still poorly understood. However, the data in the literature indicate that silymarin and silibinin act in four different ways: (i) as antioxidants, scavengers and regulators of the ...
F. Fraschini, G. Demartini, D. Esposti
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The flavonoid silymarin and one of its structural components, silibinin, are substances with documented hepatoprotective properties. Their mechanisms of action are still poorly understood. However, the data in the literature indicate that silymarin and silibinin act in four different ways: (i) as antioxidants, scavengers and regulators of the ...
F. Fraschini, G. Demartini, D. Esposti
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Hochleistungsflüssigchromatogrphie von silymarin
Journal of Chromatography A, 1978Abstract High-performance liquid chromatography of silymarin. II. Quantitative determination of silymarin from Silybum marianum by high-performance liquid chromatography The separation of the genuine silymarin, consisting of silybin, silydianin and silychristin, from the fruits of Silybum marianum Gaertn.
G. Tittel, H. Wagner
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Development of silymarin topical formulation: In vitro and ex vivo dermal kinetics of silymarin
International Journal of Pharmaceutics, 2023Silymarin constituents are extensively investigated in the treatment of skin disorders. The main constituents of silymarin include taxifolin (TX), silychristin (ST), silydianin (SDN), silybin A (SA), silybin B (SB), isosilybin A (ISA) and isosilybin B (ISB).
Vijay Kumar, Shankar +3 more
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Silymarin-induced mitochondrial Ca2+ release
Life Sciences, 1988The effect of silymarin on different functions of mitochondria isolated from rat kidneys was studied. Addition of silymarin to mitochondria oxidizing succinate, induced stimulation of the respiratory State 4; while in mitochondria oxidizing NAD-dependent substrates, the drug produced inhibition of the oxygen consumption. It is also shown that silymarin
E, Chávez, C, Bravo
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