Results 181 to 190 of about 19,240 (226)
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Silymarin, an inhibitor of prostaglandin synthetase
Experientia, 1979Silybin (I), silydianin (II) and silychristin (III), the main constituents of silymarin, inhibit the formation of prostaglandins in vitro. The inhibition is log-linearly dependent on the concentration of the effectors.
F, Fiebrich, H, Koch
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Flavonoid Antioxidant Silymarin and Skin Cancer
Antioxidants & Redox Signaling, 2002Oxidative stress is one of the key players in skin carcinogenesis, and therefore identifying nontoxic strong antioxidants to prevent skin cancer is an important area of research. In both animal and cell culture studies, we have shown that silymarin, a naturally occurring polyphenolic flavonoid antioxidant, exhibits preventive and anticancer effects ...
Rana P, Singh, Rajesh, Agarwal
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Protection against thallium hepatotoxicity by Silymarin
Journal of Applied Toxicology, 1988AbstractThe effect of silymarin (100 mg/kg i.p.) on the biochemical indicators of liver damage induced by thallium (10 mg/kg p.o.) was studied in rats. The production of malondialdehyde and the content of reduced glutathione in the liver were measured as indicators of lipid peroxidation.
M, Mourelle, L, Favari, J L, Amezcua
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Silymarin Ameliorates Gentamicin Nephrotoxicity
1989Gentamicin (GM) nephrotoxicity is most evident in the proximal tubules which sustain injury as a result of membrane-related events (1–3). Silymarin (SL), an extract from the plant milk thistle, has been shown to exert membrane protective effects (4). The possibility that silymarin may prevent or ameliorate GM-induced nephrotoxicity is investigated in a
M. K. Chan, W. L. Ng
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Patented Bioavailability Enhancement Techniques of Silymarin
Recent Patents on Drug Delivery & Formulation, 2010The present article dwells in reviewing critically the patents published mainly on the new emerging trends and techniques for increasing the bioavailability of silymarin, the polyphenolic fraction obtained from the seeds of Silybum marianum. The use of this herb for treating various ailments like hepatitis, cirrhosis, jaundice, mushroom and toxin ...
Shamama, Javed +2 more
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Silymarin and hepatoprotection.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2013To determine the hepatoprotective effect of silymarin with Chang cell cultures. Specifically, to investigate the antioxidant properties of silymarin and its protective function in reducing pro-apoptotic markers.Intracellular free radical levels were assessed with dichlorofluorescein (DCF) fluorescence after exposing cells to an oxidative stress of 400 ...
Frank J, Burczynski +5 more
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[Hepatoprotective properties of silymarin].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2011Different approaches to liver-specific medicines, particularly silymarin, which exist in russian and foreign hepatology leads to formation of some difficulties in their medical usage. There is a necessity to discuss classification and terminology aspects and to study study present evidence about silymarin medicines content, pharmacokinetic and ...
A V, Matveev +3 more
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Assessment of drug–drug interaction for silymarin
Toxicology in Vitro, 2008Silymarin was assessed for drug-drug interaction by permeability studies with Caco-2 cells, for cytochrome P450 induction with human primary hepatocytes and for cytochrome P450 inhibition with human liver microsomes. Studies with Caco-2 cells revealed no interference of silymarin with the permeability of nifedipine. Silymarin did not induce cytochromes
Johannes, Doehmer +5 more
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Silymarin and hepatocellular carcinoma
Anti-Cancer Drugs, 2015The blessed milk thistle (Silybum marianum L.), a flowering plant native to Mediterranean Europe, has been consumed and extensively used as a cure for various chronic liver ailments over several centuries. Milk thistle extract, known as silymarin, is a complex mixture of seven major flavonolignans and one flavonoid.
Jeanetta K, Mastron +3 more
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