Silybin Cocrystals with Improved Solubility and Bioavailability [PDF]
PharmaceuticalsBackgroud/Objectives: Silymarin, an extract from milk thistle, is widely recognized for its therapeutic potential in treating liver disorders. However, its clinical utility is limited by the poor solubility and low bioavailability of its key active ...
Bingqing Zhu +4 more
doaj +3 more sources
Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury [PDF]
Frontiers in Pharmacology, 2017 Silybin is a secondary metabolite isolated from the seeds of blessed milk thistle (Silybum marianum) that has anti-inflammatory, antioxidative, antifibrotic, and antitumor properties. Here, we showed that silybin protected against cisplatin-induced acute
Yin Li
exaly +2 more sources
Advances in research on the mechanisms of anti-inflammation of silybin: a review [PDF]
Frontiers in ImmunologySilybin, as the main active component of milk thistle, has attracted significant attention in recent medical research due to its remarkable anti-inflammatory effect.
Yang Wang, Yongli Yang
doaj +2 more sources
Gut microbiome-induced metabolites promote the role of Silybin as adjunctive drug in HIV-positive immunological nonresponders [PDF]
Gut Microbes ReportsHIV-infected immunological nonresponders (INRs) endure persistent T-cell dysfunction and chronic inflammation, facing high risk of various complications and mortality, with no effective therapies available.
Wenli Liu +9 more
doaj +2 more sources
Looking beyond silybin: the importance of other silymarin flavonolignans [PDF]
Frontiers in PharmacologySilymarin, an extract from the seeds of milk thistle (Silybum marianum), has been widely studied and used for its hepatoprotective and pharmacological properties.
Michal Selc +3 more
doaj +2 more sources
Foliar spraying with zinc oxide nanoparticles enhances the anti-osteoporotic efficacy of the fruit extracts of Silybum marianum L. by stimulating silybin production [PDF]
Frontiers in Plant ScienceIntroductionSilybum marianum is a medicinal plant that produces silymarin, which has been demonstrated to possess antiviral, anti-neurodegenerative, and anticancer activities.
Bedoor Fahad Almulhim +6 more
doaj +2 more sources
A Comprehensive Review on the Antibacterial, Antifungal, Antiviral, and Antiparasitic Potential of Silybin [PDF]
AntibioticsSilybin, a flavonolignan extracted from the seeds of the plant species Silybum marianum (L.) Gaertn., has a variety of pharmacological activities, including antimicrobial activity against several microorganisms of clinical interest.
José Lima Pereira-Filho +8 more
doaj +2 more sources
Current Plant Biology, 2023 Milk thistle (Silybum marianum L. Gaertn.) is an important herbaceous and annual plant that is used as a pharmaceutical for the remedy and prevention of liver diseases.
Samira Jafari +5 more
doaj +1 more source
Frontiers in Neurology, 2021 Silybin, a peculiar flavonoid compound derived from the fruit and seeds of Silybum marianum, exhibits strong anti-inflammatory activities. In the present study, we found that silybin effectively alleviated experimental autoimmune encephalomyelitis (EAE),
Huan-Li Yang, Xiao-Wu Shi
doaj +1 more source
Anti-cancer efficacy of silybin derivatives -- a structure-activity relationship. [PDF]
PLoS ONE, 2013 Silybin or silibinin, a flavonolignan isolated from Milk thistle seeds, is one of the popular dietary supplements and has been extensively studied for its antioxidant, hepatoprotective and anti-cancer properties.
Chapla Agarwal +6 more
doaj +1 more source