Results 21 to 30 of about 5,855 (222)

Multiple effects of silymarin on the hepatitis C virus lifecycle [PDF]

, 2010
Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo.
Bourne, Nigel, Brimacombe, Claire L, Cao, Feng, Graf, Tyler N, Grove, Joe, Kane, Olivia J, Lohmann, Volker, Martinez, Laura E, McKeating, Jane A, Nahmias, Yaakov, Negash, Amina, Oberlies, Nicholas H, Owen, David M, Polyak, Stephen J, Pécheur, Eve-Isabelle, Tavis, John E, Wagoner, Jessica   +16 more
core   +1 more source

Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2

Frontiers in Pharmacology, 2018
Although hepatoprotective properties of silybin are well documented, the clinical therapeutic efficacy is limited by its low bioavailability due to absorption rates, extensive phase II metabolism, and biliary excretion.
Peng Xu, Peng Xu, Hua Zhou, Ya-Zhuo Li, Zhong-Wen Yuan, Chang-Xiao Liu, Liang Liu, Ying Xie   +7 more
doaj   +1 more source

Zur Stereochemie von Silybin / The Stereochemistry of Silybin

Zeitschrift für Naturforschung C, 1983
The X-ray Structure of Silybin from Silybum marianum Gaertn. was determined. The com­pound was found to be a diastereomeric mixture (1:1) in the benzodioxane part of the molecule explaining several tentative aspects about the structure known from NMR-measurements and HPLC-separations.
Hermann Lotter, Hildebert Wagner
openaire   +1 more source

New Silybin Scaffold for Chemical Diversification: Synthesis of Novel 23-Phosphodiester Silybin Conjugates [PDF]

Synlett, 2012
Silybin is the major component (ca. 30%) of the silymarin complex extracted from the seeds of Silybum marianum , with multiple biological activities operating at various cell levels. As an ongoing effort toward the exploitation of natural products as scaffolds for chemical diversification at readily accessible positions, we present here an efficient ...
Zarrelli A., Romanucci V., Della Greca M., De Napoli L., Previtera L., Di fabio Giovanni   +5 more
openaire   +2 more sources

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells [PDF]

, 2017
Silybum marianum (milk thistle) is a medicinal plant used for the treatment of various liver disorders. This study examined whether the main flavonolignans from S. marianum (i.e.
Abenavoli, Albena T. Dinkova-Kostova, Baird, Begum, Biedermann, Biedermann, Bonifaz, Borsari, Chambers, Chow, David Biedermann, Dinkova-Kostova, Dvorak, Dzubak, Fahey, Federico, Feher, Gazak, Gazak, Hayes, Jitka Ulrichová, Jiří Vrba, Krenek, Lenka Roubalová, Liang, Nioi, Prochazkova, Pyszkova, Roubalova, Surai, Tanigawa, Thongphasuk, Trouillas, Varga, Vladimír Křen, Vrba, Wang, Zhan, Zhang, Zhao   +39 more
core   +2 more sources

Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity

Pharmaceutics, 2021
We evaluated the bioavailability, liver distribution, and efficacy of silymarin-D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) solid dispersion (silymarin-SD) in rats with acetaminophen-induced hepatotoxicity (APAP) compared with silymarin ...
Im-Sook Song, So-Jeong Nam, Ji-Hyeon Jeon, Soo-Jin Park, Min-Koo Choi   +4 more
doaj   +1 more source

Silybin Prevents Prostate Cancer by Inhibited the ALDH1A1 Expression in the Retinol Metabolism Pathway

Frontiers in Cell and Developmental Biology, 2020
BackgroundSilybin was known to exert inhibition in prostate cancer, but the underlying mechanism remained largely unknown. This study was designed to find out the potential target of Silybin on prostate cancer and explore the relative mechanisms ...
Ying Jiang, Hanbing Song, Ling Jiang, Yu Qiao, Dan Yang, Donghua Wang, Ji Li   +6 more
doaj   +1 more source

Effects of oral administration of silymarin in a juvenile murine model of non-alcoholic steatohepatitis [PDF]

, 2017
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in adolescents is challenging the global care system. No therapeutic strategies have been de\ufb01ned so far, and changes in the lifestyle remain the only alternative.
Anese, Monica, Avellini, Claudio, Calligaris, Sonia, Dal Ben, Matteo, Gambaro, Sabrina E., Gazzin, Silvia, Giraudi, Pablo J., Marin, Veronica, Raseni, Alan, Rosso, Natalia, Tiribelli, Claudio   +10 more
core   +2 more sources

Engineered silybin nanoparticles educe efficient control in experimental diabetes. [PDF]

PLoS ONE, 2014
Silybin, is one imminent therapeutic for drug induced hepatotoxicity, human prostate adenocarcinoma and other degenerative organ diseases. Recent evidences suggest that silybin influences gluconeogenesis pathways favorably and is beneficial in the ...
Suvadra Das, Partha Roy, Rajat Pal, Runa Ghosh Auddy, Abhay Sankar Chakraborti, Arup Mukherjee   +5 more
doaj   +1 more source

Synergistic effects of silybin and curcumin on virulence and carbapenemase genes expression in multidrug resistant Klebsiella oxytoca

BMC Research Notes, 2022
Objective Silybin and curcumin have potential antimicrobial effects. This study aimed to evaluate the synergistic antimicrobial effects of silybin and curcumin on virulence and carbapenemase genes expression among multidrug-resistant (MDR) Klebsiella ...
Farah H. Omer, Noor S. K. Al-Khafaji, Farah Tareq Al-Alaq, Hussein O. M. Al-Dahmoshi, Mojtaba Memariani, Morteza Saki   +5 more
doaj   +1 more source