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Silybum marianum: Beyond Hepatoprotection. [PDF]
, 2015 Silybum marianum is a medicinal plant that has long been used as hepatoprotective remedy. It has been used for the treatment of numerous liver disorders characterized by functional impairment or degenerative necrosis.
Bahmani, M. +3 more
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Shipin gongye ke-ji, 2022 As a bioactive component extracted from the seed of milk thistle, silymarin has many pharmacological functions, such as liver-protective and cholagogic effect. It is categorized as a class of flavonoids, among which silybin is one of the main components.
Jinhao YAO +6 more
doaj +1 more source
Linear regression analysis of silychristin A, silybin A and silybin B contents in Silybum marianum
Natural Product Research, 2018 Quantitative correlations between the contents of the flavonolignans silychristin A and silybins A/B provide biosynthetic clues that support a pathway in which one mesomeric form of a taxifolin radical is undergoing an oxidative coupling with a coniferyl alcohol radical.
Sameh F. AbouZid +9 more
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Enhanced bioactivity of silybin B methylation products [PDF]
Bioorganic & Medicinal Chemistry, 2013 Flavonolignans from milk thistle (Silybum marianum) have been investigated for their cellular modulatory properties, including cancer chemoprevention and hepatoprotection, as an extract (silymarin), as partially purified mixtures (silibinin and isosilibinin), and as pure compounds (a series of seven isomers).
Sy-Cordero, Arlene A +9 more
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Silybin Modulates Collagen Turnover in an In Vitro Model of NASH
Molecules, 2019 Silybin has been proposed as a treatment for nonalcoholic steatohepatitis (NASH). In this study, we assessed the effect of Silybin in a well-established in vitro coculture model of early-stage NASH. LX2 and Huh7 cells were exposed to free fatty acid (FFA)
Beatrice Anfuso +3 more
doaj +1 more source
Effect of Silybin on Lipid Profile in Hypercholesterolaemic Rats [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis associated conditions, such as Coronary Heart Disease (CHD), ischaemic cerebrovascular disease and peripheral vascular disease.
Senthil Gobalakrishnan +2 more
doaj +1 more source
Journal of Pure and Applied Microbiology, 2023 SARS-CoV-2 is continually evolving with the emergence of new variants with increased viral pathogenicity. The emergence of heavily mutated Omicron (B.1.1.529) with spike protein mutations are known to mediate its higher transmissibility and immune escape
Poonam Bansal +9 more
doaj +1 more source
Antiviral activity of silymarin against chikungunya virus [PDF]
, 2015 Citation: Lani, R., Hassandarvish, P., Chiam, C. W., Moghaddam, E., Chu, J. J. H., Rausalu, K., . . . Zandi, K. (2015). Antiviral activity of silymarin against chikungunya virus. Scientific Reports, 5, 10.
Abu Bakar, S. +10 more
core +1 more source
Silybin and silymarin - new effects and applications [PDF]
Biomedical Papers, 2005 This article aims to review critically literature published mainly within this millennium on the new and emerging applications of silymarin, the polyphenolic fraction from the seeds of Silybum marianum and its main component silybin. Silymarin and silybin used so far mostly as hepatoprotectants were shown to have other interesting activities as e.g ...
Vladimír, Kren, Daniela, Walterová
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BMC Veterinary Research, 2021 Background Hepatopathies are an important group of disorders in dogs where proper nutritional care is crucial. Supplementation with a hepatoprotectant like silybin can improve liver function and should not interfere with nutrient digestibility.
Maciej Gogulski +8 more
doaj +1 more source