Explaining Uncertain Hepatoprotective Effects: When Silibinin Co-Administered with Other Drugs [PDF]
Medeniyet Medical JournalObjective: This study investigated the herb-drug interaction between silibinin and carbamazepine (CBZ) and the potential risk of adverse drug reactions (ADR) when silibinin is co-administered with other drugs.
Dong Pu +5 more
doaj +2 more sources
Enhanced therapeutic efficacy of silibinin loaded silica coated magnetic nanocomposites against Pseudomonas aeruginosa in Combination with Ciprofloxacin and HepG2 cancer cells [PDF]
Scientific ReportsSilibinin, a major bioactive compound extracted from Silybum marianum, possesses notable antioxidant, antitumor, hepatoprotective, and antibacterial activities. However, its poor solubility limits its clinical applications.
Sanaz Borji +4 more
doaj +2 more sources
Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1
Redox BiologyAcute kidney injury (AKI) is primarily caused by renal ischemia-reperfusion injury (IRI), which is one of the most prevalent triggers. Currently, preventive and therapeutic measures remain limited.
Yijian Deng +16 more
exaly +3 more sources
Poly(ethylene glycol)-poly(ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibinin [PDF]
BioImpacts, 2020 Introduction: Silibinin is a naturally occurring compound with known positive impacts on prevention and treatment of many types of human illnesses in general and cancer in particular.
Ashkan Hassankhani Rad +5 more
doaj +1 more source
Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries
Antioxidants, 2023 Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases.
Wentao Duan +11 more
doaj +1 more source
Iraqi Journal of Pharmaceutical Sciences, 2017 Previous reports demonstrated the effectiveness of silibinin hemisuccinate as a potential intraocular pressure-lowering agent. The exact mechanism by which silibinin exerted this effect has not yet been documented, but might suggested to interfere with ...
Saad A. Hussain +3 more
doaj +3 more sources
Silibinin exhibits anti-tumor effects in a breast cancer stem cell model by targeting stemness and induction of differentiation and apoptosis [PDF]
BioImpacts, 2022 Introduction: Malignant breast cancer (BC) frequently contains a rare population of cells called cancer stem cells which underlie tumor relapse and metastasis, and targeting these cells may improve treatment options and outcomes for patients with BC. The
Javad Firouzi +9 more
doaj +1 more source
Silibinin Inhibits Platelet-Derived Growth Factor-Driven Cell Proliferation via Downregulation of N-Glycosylation in Human Tenon's Fibroblasts in a Proteasome-Dependent Manner. [PDF]
PLoS ONE, 2016 The objective of this study was to evaluate the effects of silibinin on cell proliferation in platelet-derived growth factor (PDGF)-treated human Tenon's fibroblasts (HTFs).
Yi-Hao Chen +5 more
doaj +1 more source
Amelioration of amyloid beta (Aβ1-40) neurotoxicity by administration of silibinin; a behavioral and biochemical assessment [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Alzheimer’s disease (AD), the most common cause of dementia, is one of the leading causes of morbidity and death in the world. Currently, treatment mostly used to slow down the disease progression.
Tahereh Alihosseini +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed ...
Shuai Guo +9 more
doaj +1 more source