Analysis of the interaction of calcitriol with the disulfide isomerase ERp57 [PDF]
, 2016 Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane- associated receptor, which has been discovered as the ...
Altieri, Fabio +7 more
core +1 more source
Journal of Pharmacological Sciences, 2010 Hepatoprotectant silibinin has anticancer and chemo-preventive effects. In this study, silibinin showed significant inhibitory effect on human fibroblast HT 1080 cell growth cultured in media containing 10% fetal bovine serum or in serum free media, and ...
Wenjun Duan +5 more
doaj +1 more source
Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis [PDF]
, 2016 Background: Silibinin, a biologically active compound of milk thistle, has chemopreventive effects on cancer cell lines. Recently it was reported that silibinin inhibited tumor growth through activation of the apoptotic signaling pathway.
A Deniaud +51 more
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Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis. [PDF]
, 2012 Nonalcoholic steatohepatitis (NASH) is associated with increased liver-related mortality. Disturbances in hepatic lipid homeostasis trigger oxidative stress and inflammation (ie, lipotoxicity), leading to the progression of NASH.
Barbagallo, I +5 more
core +1 more source
Protective effects of silibinin on LPS-induced inflammation in human periodontal ligament cells
Frontiers in Chemistry, 2022 Clinically, periodontitis is a chronic nonspecific inflammation that leads to damaged teeth and their supporting gum tissues. Although many studies on periodontitis have been conducted, therapy with natural products is still rare.
Di Meng +3 more
doaj +1 more source
Dracocephalum tanguticum Maxim Polysaccharide Ameliorate Autoimmune Hepatitis via Regulating TNF and IL‐17 Signaling Pathways [PDF]
Food Sci NutrDrTPs were obtained using the water extraction‐ethanol precipitation method. Autoimmune hepatitis (AIH) models of both mice and ALM12 cells were produced by ConA. The serum liver function indexes (AST and ALT) were examined by ELISA, and liver tissue pathological changes were observed by HE staining.
Guo M, Wei S, Cheng B, Li X.
europepmc +2 more sources
BMC Complementary Medicine and Therapies, 2021 Background Silibinin, as a chemopreventive agent, has shown anti-cancer efficacy against different types of cancers. In the present study, we investigated the anti-cancer activities of silibinin on CT26 mouse colon cell line.
Saba Sameri +3 more
doaj +1 more source
New silibinin glyco-conjugates: Synthesis and evaluation of antioxidant properties [PDF]
, 2014 New silibinin glyco-conjugates have been synthesized by efficient method and in short time. Exploiting our solution phase strategy, several structurally diverse silibinin glyco-conjugates (gluco, manno, galacto, and lacto-) were successfully realized in ...
Alessandro Federico +6 more
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Silibinin treatment prevents endotoxin-induced uveitis in rats in vivo and in vitro. [PDF]
PLoS ONE, 2017 Uveitis, an intraocular inflammatory disease, occurs mostly in young people and can result in the loss of socioeconomic capabilities. Silibinin has been shown to exert anti-inflammatory effects in human retinal pigment epithelial (RPE) cells. The present
Ching-Long Chen +5 more
doaj +1 more source
Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2011 A new complex of the oxovanadium(IV) cation with the flavolignan silibinin has been synthesized and characterized. Vanadium compounds show interesting biological and pharmacological properties and some of them display antitumoral actions. Flavonoids are part of a larger group of antioxidant compounds called polyphenols which may inhibit the ...
Naso, Luciana G. +7 more
openaire +4 more sources