Silibinin Effect on Methotrexate-Induced Hepatotoxicity in Rats
The Eurasian Journal of Medicine, 2022 Hepatotoxicity is one of the major side effects of methotrexate and limits its use. In this study, we investigated the hepatoprotective effect of silibinin and the role of oxidative stress markers and cytokines on high-dose methotrexate-induced hepatotoxicity in rats.In this study, rats were randomly divided into 5 groups (n=7). Methotrexate (20 mg/kg,
Yanaşoğlu, Emine +6 more
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Liver transplantation: a life-saving procedure following amatoxin mushroom poisoning [PDF]
, 2017 published_or_final_versio
CK Chan +8 more
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Journal of Experimental & Clinical Cancer Research, 2011 Background Silibinin, a natural polyphenolic flavonoid, has been reported to induce cell death in various cancer cell types. However, the molecular mechanism is not clearly defined.
Kim Yong K +6 more
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Effect of silibinin in reducing inflammatory pathways in in vitro and in vivo models of infection-induced preterm birth. [PDF]
PLoS ONE, 2014 Infection-induced preterm birth is the largest cause of infant death and of neurological disabilities in survivors. Silibinin, from milk thistle, exerts potent anti-inflammatory activities in non-gestational tissues.
Ratana Lim +3 more
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NADH autofluorescence, a new metabolic biomarker for cancer stem cells : identification of Vitamin C and CAPE as natural products targeting “stemness” [PDF]
, 2017 Here, we assembled a broad molecular “tool-kit” to interrogate the role of metabolic heterogeneity in the propagation of cancer stem-like cells (CSCs).
Abramov +33 more
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Lung Cancer Management with Silibinin: A Historical and Translational Perspective
Pharmaceuticals, 2021 The flavonolignan silibinin, the major bioactive component of the silymarin extract of Silybum marianum (milk thistle) seeds, is gaining traction as a novel anti-cancer therapeutic.
Sara Verdura +6 more
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Combination of Silibinin and Curcumin Reduced Leptin Receptor Expression in MCF-7 Human Breast Cancer Cell Line [PDF]
Iranian Journal of Medical Sciences, 2020 Background: Leptin and leptin receptor (Ob-R) are associated with worse prognosis, distant metastasis, and poor survival of breast cancer. We investigated the cytotoxic effect of silibinin and curcumin, individually and combined, on Ob-R expression in ...
Somaye Dalimi-Asl +2 more
doaj +1 more source
Wound healing activity of silibinin in mice
Pharmacognosy Research, 2016 Silibinin is a semi-purified fraction of silymarin contained in milk thistle (Silybum marianum Asteraceae). Primarily known for its hepatoprotective actions, silymarin may also stimulate epithelialization and reduce inflammation in excision wound. Previous studies show antioxidant, anti-inflammatory, and antimicrobial actions of silibinin.
Samanta, Rojalini +5 more
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Epigenetic activities of flavonoids in the prevention and treatment of cancer [PDF]
, 2015 Aberrant epigenetic modifications are described in an increasing number of pathological conditions, including neurodegenerative diseases, cardiovascular diseases, diabetes mellitus type 2, obesity and cancer.
Christian Busch +5 more
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Natural Product Communications, 2016 The present study assessed comparatively the antioxidant activities of silymarin and its major active component silibinin and their neuroprotective effects against hydrogen peroxide (H 2 O 2 )-induced oxidative stress in rat pheochromocytoma PC12 cells ...
Hui-Hui Jiang +3 more
doaj +1 more source