Results 61 to 70 of about 10,310 (224)
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway
Frontiers in Pharmacology, 2022 Background: Silibinin is widely utilized drug in various cancer treatments, though its application in cholangiocarcinoma has not yet been explored. For the first time, we evaluated the anticancer potential and underlying molecular mechanism of silibinin ...
Yang Bai +6 more
doaj +1 more source
Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.Chronic inflammation in diabetic foot ulcers elevates MMP activity and suppresses TIMP and growth factor signaling, impairing tissue repair. Phytochemicals modulate NF‐κB/MAPK pathways and enhance Nrf2–TIMP expression, restoring MMP/TIMP balance, promoting collagen deposition, angiogenesis, and re‐epithelialization, leading to effective wound healing ...
Vishnu Priyan Elaiyaraja +3 more
wiley +1 more source
Influence of ellagitannins extracted by pomegranate fruit on disulfide isomerase PDIA3 activity [PDF]
, 2019 Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid,
Altieri, Fabio +6 more
core +1 more source
Frontiers in Bioscience-Landmark, 2023 Background and Aims: Normal cells become tumorigenic owing to mutations in oncogenes and tumor suppressor genes modulating cell division. Cancer cells break down extracellular matrix to metastasize other tissues. Therefore, the development of natural and
Ah In Jo, Moon-Moo Kim
doaj +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini +7 more
wiley +1 more source
STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]
, 2018 Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F +7 more
core +2 more sources
Pharmacokinetics and safety of silibinin in horses
American Journal of Veterinary Research, 2013 Abstract Objective—To determine the oral bioavailability, single and multidose pharmacokinetics, and safety of silibinin, a milk thistle derivative, in healthy horses. Animals—9 healthy horses. Procedures—Horses were initially administered silibinin IV and silibinin phospholipid orally in feed and via nasogastric tube.
Eileen S, Hackett +3 more
openaire +2 more sources
Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions
MedComm, Volume 7, Issue 5, May 2026.We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu +8 more
wiley +1 more source
Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy [PDF]
, 2014 published_or_final_versio
CHEUNG, F +7 more
core +3 more sources
Effects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Liver ischemia-reperfusion injuries (I/RI) are typically the main causes of liver dysfunction after various types of liver surgery especially liver transplantation. Radical components are the major causes of such direct injuries.
Vahid Akbari-Kordkheyli +2 more
doaj +1 more source