Silibinin improved the function of T cells in peripheral blood mononuclear cells (PBMCs) co-cultured with U-87 MG cell line [PDF]
Avicenna Journal of PhytomedicineObjective: Silibinin has exhibited antitumor activities. However, there are few reports about the immunomodulatory properties of silibinin on T lymphocyte function in the tumor microenvironment.
Banafshe Abadi +4 more
doaj +1 more source
Fabrication and Characterization of Silibinin-loaded Liposomes for Skin Wounds Healing [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2023 Background and Objectives: Silibinin, an antioxidant, is used to prevent and treat skin inflammatory disorders. This study aimed to develop a liposomal silibinin formulation to increase its bioavailability and water solubility and control its kinetic ...
Mohammad Taebpour +3 more
doaj
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
Current Issues in Molecular Biology, 2023 This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis.
Kyung-Hoon Sun +2 more
openaire +3 more sources
Natural Antioxidants as Thermal Stabilizers in Post‐Consumer Polypropylene
Journal of Applied Polymer Science, EarlyView.A synergistic antioxidant system combining two natural antioxidants, quercetin and tocopherol, enhances the thermo‐oxidative stability of recycled polypropylene. The approach addresses key barriers to the utilization of recycled polymers, offering a sustainable pathway to improve material performance and supporting the broader adoption of recycled ...
Jeevan Tom Joseph +3 more
wiley +1 more source
A high-fat diet containing whole walnuts (Juglans regia) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model. [PDF]
, 2012 Prostate cancer (PCa) has been linked to fat intake, but the effects of both different dietary fat levels and types remain inconsistent and incompletely characterised.
Cross, Carroll E +6 more
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BioImpacts, 2013 Introduction: Nowadays, using drug delivery is an essential method to improve cancer therapy through decreasing drug toxicity and increasing efficiency of treatment.
Zohreh Ebrahimnezhad +7 more
doaj +1 more source
The Effect of Silibinin on the Expression of TLR7, ISG15, and SOCS1 in Peripheral Blood Mononuclear Cells of Hepatitis C Infected Patients in Comparison with Interferon-α [PDF]
Journal of Medical Microbiology and Infectious Diseases, 2021 Introduction: Silibinin (silibinin A) is the most active silymarin component, which acts both as a hepatoprotective [1] and an antiviral agent. The present study investigated the silibinin effect on IFN-related innate immune genes in PBMCs from HCV ...
Razieh Dowran +3 more
doaj
Cells, 2021 Recently, natural compounds have been used globally for cancer treatment studies. Silibinin is a natural compound extracted from Silybum marianum (milk thistle), which has been suggested as an anticancer drug through various studies.
Alexis Rugamba +6 more
doaj +1 more source
A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation
Food Chemistry International, EarlyView.Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee +4 more
wiley +1 more source
Glucose addiction in cancer therapy : advances and drawbacks [PDF]
, 2015 Glucose addiction in cancer therapy: advances and drawbacks.In contrast to differentiated normal cells, which primarily use mitochondrial respiration to generate the energy needed for cellular processes, most cancer cells rely on glycolysis, even in ...
Baltazar, Maria de Fátima Monginho +4 more
core +1 more source