Results 41 to 50 of about 5,855 (222)

Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]

, 2015
Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu, Oga, Enoche Florence, Sekine, Shuichi, Shitara, Yoshihisa   +3 more
core   +1 more source

The Comparison of The Effects of Silybin and Silybin-Phosphatidylcholine on Viability and ESR Expression in Human Breast Cancer T47D Cell Line [PDF]

Cell Journal, 2014
Objective: Silybin is a polyphenol with anti-oxidant and anti-cancer properties. The poor bioavailability of some polyphenols can be improved by binding to phosphatidylcholine.
Narges Mahmoodi, Nasrin Motamed, Seyed Hassan Paylakhi   +2 more
doaj  

Silybin Derivatives Produced by γ-Irradiation and Their Tyrosinase Inhibitory Activities

Molecules
Silybin, which belongs to the flavonolignan group, is the major component of the fruit extract of Silybum marianum (common name: milk thistle). Silybin is a medicinal compound with hepatoprotective, antioxidant, and anticancer properties.
Ah-Reum Han, Hyung Won Ryu, Chang Hyun Jin   +2 more
doaj   +1 more source

Silybins are stereospecific regulators of the 20S proteasome

Bioorganic & Medicinal Chemistry, 2022
A reduced proteasome activity tiles excessive amyloid growth during the progress of protein conformational diseases (PCDs). Hence, the development of safe and effective proteasome enhancers represents an attractive target for the therapeutic treatment of these chronic disorders.
Persico, Marco, García-Viñuales, Sara, Santoro, Anna Maria, Lanza, Valeria, Tundo, Grazia Raffaella, Sbardella, Diego, Coletta, Massimiliano, Romanucci, Valeria, Zarrelli, Armando, Di Fabio, Giovanni, Fattorusso, Caterina, Milardi, Danilo   +11 more
openaire   +7 more sources

Purification, identification, and standardization of silybin A & B composition from Silybum marianum (L.) Gaertn.

Journal of Medicinal Plants, 2022
Background: Silybum marianum (L.) Gaertn. (Milk thistle) is a perennial herb with medicinal properties. The seeds of these plants contain silymarin compounds with flavonolignan structure and antioxidant, anti-inflammatory and hepatoprotective effects ...
Saeed Tavakoli, Farahnaz Khalighi-Sigaroodi, Reza Hagiaghaee, Mahdi Yaghoobi, Reza Ghafarzadegan   +4 more
doaj  

Ultrasonic-assisted enzymatic extraction of silymarin from the Silybum marianum seed shell and evaluation of its antioxidant activity in vitro [PDF]

, 2015
This study revealed the optimal conditions for the Ultrasonic-Assisted Enzymatic Extraction (UAEE) of silymarin, and include: the concentration of ethanol, 50 %; enzyme concentration, 30 U/mg; liquid-solid ratio, 6:1; an extraction time of 120 min; and ...
Li, XinHua, Zhao, Fei
core   +1 more source

Superior silybin bioavailability of silybin–phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers*

BMC Pharmacology and Toxicology, 2019
Background Fibrosis is a response to chronic liver disease that results in excessive accumulation of extracellular matrix proteins and formation of scar tissue. Fibrosis represents a clinical challenge of worldwide significance.
Nahum Méndez-Sánchez, Miguel Dibildox-Martinez, Jahir Sosa-Noguera, Ramón Sánchez-Medal, Francisco J. Flores-Murrieta   +4 more
doaj   +1 more source

Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis. [PDF]

, 2012
Nonalcoholic steatohepatitis (NASH) is associated with increased liver-related mortality. Disturbances in hepatic lipid homeostasis trigger oxidative stress and inflammation (ie, lipotoxicity), leading to the progression of NASH.
Barbagallo, I, CAPPELLO, Francesco, Galvano, F, Li Volti, G., Mangameli, A, Salamone, F   +5 more
core   +1 more source

Silybin Showed Higher Cytotoxic, Antiproliferative, and Anti-Inflammatory Activities in the CaCo Cancer Cell Line while Retaining Viability and Proliferation in Normal Intestinal IPEC-1 Cells

Life, 2023
The anticancer potential of silymarin is well known, including its anti-inflammatory as well as antiproliferative effect mediated by influencing the cell cycle, suppression of apoptosis, and inhibition of cell-survival kinases.
Dominika Faixová, Marek Ratvaj, Ivana Cingeľová Maruščáková, Gabriela Hrčková, Viera Karaffová, Zita Faixová, Dagmar Mudroňová   +6 more
doaj   +1 more source

Drugs and herbs given to prevent hepatotoxicity of tuberculosis therapy: systematic review of ingredients and evaluation studies [PDF]

, 2008
Background: Drugs to protect the liver are frequently prescribed in some countries as part of treatment for tuberculosis. The biological rationale is not clear, they are expensive and may do harm.
Qin Liu, Paul Garner, Yang Wang, Binghua Huang, Helen Smith, MJ Ho, F Stickel, M Steele, YJ Guo, DR Zhang, DY Hu, S Zhan, World Health Organization Division of Traditional Medicine, R Wang, LM Li, VK Singh, QH Huang, LA Galitskií, HR Li, BC Xing, Q Liu, XM Zheng, XP Hao, HR Li, W Bao, GF An, AG Dong, Y Gao, ZH Huang, HY Zhang, Z Zhang, L Tian, YJ Wei, J Chang, YX Chen, XH Chen, ZJ Chai, LJ Fu, NP Skakun, Wl Zhu, JF Cheng, GP Jin, Sl Yu, JQ Xiao, YM Wu, SW Kang, HQ Pan, JF Ge, L Tian, P Zhang, YM Li, SL Liang, BQ Fu, B Chen, YK Chen, KZ Du, SV Dange, OI Katikova, S Yang, Y Yuan, P Sun, QH Zhang, XF Zhang, WL Wang, JF Cheng, LF He, X Zhang, CJ Ye, RM Sun, ZD Wang, Q Zhu, FJ Liu, LW Wu, ZC Niu, GY Ding, B Liu, K Lan, Q Tan, ZG Bi, LL Liang, B Quan, LY Ma, JJ Wu, J Liu, XL Li, L Wang, XL Wu, JG Lin, TM Feng, DN Lei, XP Sun, XY Liu, W Cui, So Hrechin, SL Lv, G Niu, YW Qu   +96 more
core   +5 more sources