Results 61 to 70 of about 5,855 (222)

cis–trans Isomerization of silybins A and B [PDF]

Beilstein Journal of Organic Chemistry, 2014
Methods were developed and optimized for the preparation of the 2,3-cis- and the 10,11-cis-isomers of silybin by the Lewis acid catalyzed (BF3∙OEt2) isomerization of silybins A (1a) and B (1b) (trans-isomers). The absolute configuration of all optically pure compounds was determined by using NMR and comparing their electronic circular dichroism data ...
Novotna, M., Gazak, R., Biedermann, D., Di Meo, Florent, Marhol, P., Kuzma, M., Bednarova, L., Fuksova, K., Trouillas, P., Kren, V.   +9 more
openaire   +4 more sources

The Herbal Pair Daphniphyllum calycinum–Polygonum hydropiper Alleviates Gastric Mucosal Injury via Regulating Autophagy and Targeting the TLR4/NF‐κB/NLRP3 Pathway

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
The schematic diagram illustrated the proposed mechanism of DCPH in mouse macrophages. DCPH promotes autophagy to suppress the TLR4/NF‐κB/NLRP3 pathway and M1 polarization, thereby attenuating cellular oxidative stress and inflammation. ABSTRACT Gastric mucosal injury refers to the pathological changes characterized by congestion, edema, bleeding and ...
Yunyun Zhi, Keli Zhou, Xueqing Huang, Yonghui Li, Ye Zhu, Yiqiang Xie, Shouzhong Ren   +6 more
wiley   +1 more source

Longchai Decoction Treated the Fibrosis of Liver Induced by CCl4 Regulates Nrf2/GPX4 Pathway to Suppress Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT The aim of the study is to evaluate the therapeutic efficacy of Longchai Decoction (LCD), an empirical traditional Chinese medicine formula for liver disorders, on liver fibrosis (LF) and to elucidate its molecular mechanisms. A mouse model of LF and an erastin‐induced ferroptosis model was established in LX‐2 cells, which were then treated ...
Hui Wang, Liang Wang, Fangshi Zhu, Siru Chen   +3 more
wiley   +1 more source

Effects of silybin on growth performance, antioxidant capacity and immunity in juvenile hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂) fed with high-lipid diets

Aquaculture Reports
This research examined the impacts of varying silybin dosages in high-lipid diets on the growth, hepatic histology, immunity, and immune-related gene expression of juvenile hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂).
Mingsheng Xie, Hao Liu, Weibin Huang, Menglong Zhou, Shuang Zhang, Beiping Tan, Shuyan Chi, Yuanzhi Yang, Xiaohui Dong   +8 more
doaj   +1 more source

Új antioxidáns hatású molekulák szintézise és hatásmechanizmusuk vizsgálata = Synthesis of novel antioxidants and investigation of mechanism of action [PDF]

, 2007
A lilavirágú Máriatövisban található silybin és szintetikus származékainak antioxidáns hatását vizsgáltuk különböző rendszerekben (neutrofilek forbol-észter stimulálta szuperoxid anion termelés, xantin oxidáz aktivitás, gyökfogó képesség), azzal a céllal,
Antus, Sándor, Varga, Zsuzsa, Újhelyi, László   +2 more
core  

Glucose addiction in cancer therapy : advances and drawbacks [PDF]

, 2015
Glucose addiction in cancer therapy: advances and drawbacks.In contrast to differentiated normal cells, which primarily use mitochondrial respiration to generate the energy needed for cellular processes, most cancer cells rely on glycolysis, even in ...
Baltazar, Maria de Fátima Monginho, Granja, Sara Costa, Martinho, Olga, Pinheiro, Céline, Reis, R. M.   +4 more
core   +1 more source

Natural antioxidants and vascular calcification: a possible benefit? [PDF]

, 2013
Background: Several studies have demonstrated the impact of vascular calcification on morbidity and mortality both in the general and chronic kidney disease populations.
Barrio-Vázquez, Sara, Cannata, J.B. (Jorge), Fernández-Martín, J.L. (José), Román-García, Pablo, Ruiz-Torres, M.P. (María)   +4 more
core  

Total synthesis of (.+-.)-silybin, an antihepatotoxic flavonolignan.

Chemical and Pharmaceutical Bulletin, 1985
The flavonolignan (±)-silybin (1), having an antihepatotoxic activity, has been synthesized via a key intermediate (9), which was prepared from readily available starting materials (2) and (3). The aldehyde (9) was transformed to the methoxymethyl ether (10), which was condensed with an acetophenone derivative (11) to yield the chalcone (12). Oxidation
H, Tanaka, M, Shibata, K, Ohira, K, Ito
openaire   +3 more sources

The role of cytokines in ovarian cancer drug resistance

International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.
Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang, Yunxia Zang, Rebeka Dejenie, Junyuan Bing, Shixia Dong, Yanfei Zhang, Yi Zhu, Jingjing Li   +7 more
wiley   +1 more source

Therapeutic Potential of Saikosaponins in MASLD and Cross‐Organ Protection: A Research Update

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This review systematically outlines the multi‐target mechanisms of Saikosaponins (SSs) against MASLD, encompassing the regulation of lipid metabolism, insulin resistance, and inflammatory response. Furthermore, it highlights their novel cross‐organ protective effects on the cardiovascular, renal, and central nervous systems, providing therapeutic ...
Jiayao Xiong, Wanyan Tan, Ze Jin, Xiangyu Li, Yuting Chen, Wanting Xie   +5 more
wiley   +1 more source