Results 81 to 90 of about 5,855 (222)

ADME/Tox Properties and Biochemical Interactions of Silybin Congeners: Study

Natural Product Communications, 2017
Silymarin, the active constituent of Silybum marianum (milk thistle), and its main component, silybin, are products with well-known hepatoprotective, cytoprotective, antioxidant, and chemopreventative properties.
Antonia Diukendjieva, Merilin Al Sharif, Petko Alov, Tania Pencheva, Ivanka Tsakovska, Ilza Pajeva   +5 more
doaj   +1 more source

The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression

Frontiers in Nutrition, 2017
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and mortality. Oxidative stress and release of pro-inflammatory cytokines, such as tumor necrosis factor α (TNFα), are major consequences of hepatic lipid overload ...
Giulia Vecchione, Elena Grasselli, Federica Cioffi, Francesca Baldini, Paulo J. Oliveira, Vilma A. Sardão, Katia Cortese, Antonia Lanni, Adriana Voci, Piero Portincasa, Laura Vergani   +10 more
doaj   +1 more source

The Effect of Water Extracted Silibinin on Reactive Oxygen Species (ROS) Production of Macrophages [PDF]

, 2008
The world is actively looking for technology to produce sustainable liquid fuels to replace our reliance on petroleum-based fuels. Biomass can be converted either through the thermochemical or saccharification platforms into fuels such as ethanol or ...
Abbott, Julie, Carrier, Danielle, Clausen, Ed, Wallace, Sunny   +3 more
core   +1 more source

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

Food Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dietrich Büsselberg, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Edgar Yebrán Villegas‐Vázquez, Hernán Cortés, Gerardo Leyva‐Gómez, Jesús Herrera‐Bravo, Solomon Habtemariam, Javad Sharifi‐Rad, Monica Butnariu, Cristian Berar, Angela Caunii, William C. Cho   +15 more
wiley   +1 more source

A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B [PDF]

, 2015
Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. a-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure.
A Onufriev, A Zheleva, A Zheleva, Alexandra T. P. Carvalho, AP Zavascki, BD Beck, BK Wills, C Gao, CA Beelman, CN Broussard, CW Pinson, DA Bushnell, DA Case, Daniel F. A. R. Dourado, DJ Barbosa, DR Larson, E Kaya, Félix Carvalho, G Leclerc, G Vogel, GM Morris, I Dalle-Donne, I-M Chang, J Garcia, J Garcia, J Guhaniyogi, J He, J Ross, J Vetter, J Weiser, J Zhao, JB Mowry, JL Dores-Sousa, José Alberto Duarte, Juliana Garcia, KH Reuner, M Leist, M Mydlik, MA Koda-Kimble, Marcelo D. Arbo, Maria de Lourdes Bastos, MM Murr, P Poucheret, PA Kollman, Paula Baptista, PCK Cheung, Ricardo Jorge Dinis-Oliveira, Ricardo Silvestre, SM Schneider, SM Schneider, T Lawrence, T Wieland, T Wieland, TC Tong, Teresa Baltazar, V Fineschi, Vera Marisa Costa, XP Zhang, Y Yamaura, YF Zhao   +59 more
core   +1 more source

Applications of Chitosan, an Eco‐Friendly Biopolymer in Agricultural Systems, Herbal Products, and Functional Foods: A Review

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Chitosan is highlighted for its industrial applications include food processing and preservation, pharmaceuticals, agriculture systems, and environmental protection. ABSTRACT Chitin, the natural biopolymer of the world next to cellulose, is a modified biodegradable polysaccharide.
Saeedeh Karimlar, Abdollah Ghasemi Pirbalouti, Zahra Teymuori, Maryam Moslehishad, Zohreh Hamidi‐Esfahani   +4 more
wiley   +1 more source

Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy [PDF]

, 2018
Hepatitis C virus (HCV) infection commonly causes progressive liver diseases that deteriorate from chronic inflammation to fibrosis, cirrhosis and even to hepatocellular carcinoma.
Huang, Meng-Hao, Jiang, Jian-Dong, Li, Hu, Peng, Zong-Gen   +3 more
core   +2 more sources

Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression

Fitoterapia, 2018
Despite significant advances in the diagnosis and treatment of cancer, the development of drug resistance still remains one of the principal causes that hampers the effectiveness of the therapy. Emerging evidences support the idea that the dysregulated metabolism could be related to drug resistance.
Catanzaro, Daniela, Gabbia, Daniela, Cocetta, Veronica, Biagi, Marco, Ragazzi, Eugenio, Montopoli, Monica, Carrara, Maria   +6 more
openaire   +5 more sources

Integrated Network Pharmacology, Single‐Cell Transcriptomics Unveil the Mechanistic Role of Morusin in Aortic Dissection

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Aortic dissection is a life‐threatening cardiovascular emergency with limited pharmacological options. This study focuses on elucidating the multi‐target and multi‐pathway mechanisms through which morusin mitigates aortic dissection progression, integrating network pharmacology, single‐cell transcriptomics and experimental validation.
Zhaomeng Wang, Haoran Zhang, Zhanxiong Xie, Yukun Xiang, Yiwen Fu, Zixun Wang, Haiqing Jiao, Nan Lin, Chenguang Niu, Chao Jiang, Lemin Zheng   +10 more
wiley   +1 more source

Advances in pharmacological studies of silymarin

Memorias do Instituto Oswaldo Cruz, 1991
Silymarin is the flavonoids extracted from the seeds of Silybum marianum (L) Gearth as a mixture of three structural isomers: silybin, silydianin and silychristin, the former being the most active component. Silymarin protects liver cell membrane against
Yao-Cheng Rui
doaj   +1 more source