Results 101 to 110 of about 5,855 (222)

Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages

Molecules, 2015
Silymarin is a hepatoprotective mixture of flavonolignans and flavonoids extracted from the seeds of milk thistle (Silybum marianum L. Gaertn). This study investigates the effect of major bioactive constituents from silymarin, silybin A, silybin B ...
Limei Wang, Susanne Rotter, Angela Ladurner, Elke H. Heiss, Nicholas H. Oberlies, Verena M. Dirsch, Atanas G. Atanasov   +6 more
doaj   +1 more source

Silybin and metabolic disorders [PDF]

Internal and Emergency Medicine, 2018
Pignatelli P., Carnevale R., Menichelli D.   +2 more
openaire   +3 more sources

Effect of silybin on high-fat-induced fatty liver in rats

Brazilian Journal of Medical and Biological Research, 2011
Silybin, a natural antioxidant, has been traditionally used against a variety of liver ailments. To investigate its effect and the underlying mechanisms of action on non-alcoholic fatty liver in rats, we used 60 4-6-week-old male Sprague-Dawley rats to ...
Jiayin Yao, Min Zhi, Chen Minhu
doaj   +1 more source

Impact of in utero exposure to EtOH on corpus callosum development and paw preference in rats: protective effects of silymarin [PDF]

, 2002
Background Using a rat model we have found that the bioflavonoid silymarin (SY) ameliorates some of the negative consequences of in utero exposure to ethanol (EtOH).
Nicol Moreland, Linda La Grange, Rebecca Montoya, B Zimmerberg, R Riikonen, SL Archibald, FL Bookstein, MA Jeeves, MW Miller, SN Mattson, CL Coulter, JS Jeret, B Zimmerberg, W London, B Zimmerberg, K Flora, J Sonnenbichler, R Locher, A Valenzuela, C Dehmlow, J Edwards, L La Grange, A Busby, C Reid, E Sowell, S Pence, B Zimmerberg, RJ Handa, J Weinberg, RF McGivern, J Dahlgren, E Halmesmäki, C Roselli, F Naftolin, RH Fitch, HA Bimonte   +35 more
core   +2 more sources

Free Radical Scavenging and Antioxidant Activities of Silymarin Components

Antioxidants, 2013
Silymarin is an over the counter food supplement that is sold as a liver enhancement and liver protection preparation. It is a major constituent of the seeds of Silybum marianum which is composed of a mixture of seven major components and several minor ...
Kevin P. Anthony, Mahmoud A. Saleh
doaj   +1 more source

The effect of silymarin on liver injury induced by Thioacetamide in rats [PDF]

, 2013
Introduction: In this study the protective effects of Silymarin was investigated against thioacetamide (TAA) induced hepatotoxicity in rat. Methods: In an experimental study 24 male Wistar rats were designated in four equal groups as follows: Control ...
Ahangar Darabi, Mahboobeh., Kabiri, najmeh., Rafieian-Kopaei, Mahmoud., Setorki, Mahbubeh.   +3 more
core  

Metabolism, Transport and Drug–Drug Interactions of Silymarin

Molecules, 2019
Silymarin, the extract of milk thistle, and its major active flavonolignan silybin, are common products widely used in the phytotherapy of liver diseases.
Ying Xie, Dingqi Zhang, Jin Zhang, Jialu Yuan   +3 more
doaj   +1 more source

7-O-tyrosyl Silybin Derivatives as a Novel Set of Anti-Prostate Cancer Compounds

Antioxidants
Silybin is a natural compound extensively studied for its hepatoprotective, neuroprotective and anticancer properties. Envisioning the enhancement of silybin potential by suitable modifications in its chemical structure, here, a series of new 7-O-alkyl ...
Valeria Romanucci, Rita Pagano, Kushal Kandhari, Armando Zarrelli, Maria Petrone, Chapla Agarwal, Rajesh Agarwal, Giovanni Di Fabio   +7 more
doaj   +1 more source

Silymarin ameliorates metabolic dysfunction associated with Diet-induced Obesity via activation of farnesyl X receptor

Frontiers in Pharmacology, 2016
BACKGROUND AND PURPOSESilymarin, a standardized extract of the milk thistle seeds, has been widely used to treat chronic hepatitis, cirrhosis and other types of toxic liver damage. .
Ming Gu, Ping Zhao, Jinwen Huang, Yuanyuan Zhao, Yahui Wang, Yin Li, Shengjie Fan, Yifei Li, Yue-Ming Ma, Qingchun Tong, Li Yang, Guang Ji, Cheng Huang   +12 more
doaj   +1 more source

Kutkins- A Review of Chemistry and Pharmacology [PDF]

, 2004
Kutkins are group of pharmacologically active compounds present in Picrorhiza kurroa Royle (Scrophulariaceae). Picrorhiza kurroa is traditionally known as kutki and has intense bitter taste.
Singh, Amrit Pal
core   +2 more sources