Results 91 to 100 of about 5,855 (222)

Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-Inflammatory Potential

Antioxidants, 2020
Silybin is considered to be the main biologically active component of silymarin. Its oxidized derivative 2,3-dehydrosilybin typically occurs in silymarin in small, but non-negligible amounts (up to 3%).
Simona Dobiasová, Kateřina Řehořová, Denisa Kučerová, David Biedermann, Kristýna Káňová, Lucie Petrásková, Kamila Koucká, Radka Václavíková, Kateřina Valentová, Tomáš Ruml, Tomáš Macek, Vladimír Křen, Jitka Viktorová   +12 more
doaj   +1 more source

Milk thistle (Silybum marianum) [PDF]

, 2006
Milk thistle is a commonly used herb for hepatic function and disorders.
Staff, Clinic
core   +1 more source

Safeguarding Spermatogenesis: Garcinia kola Extract and Kolaviron Effectively Ameliorate Testicular Toxicity in Rats Treated With Bleomycin, Etoposide, and Cisplatin Combination Therapy

Andrologia, Volume 2026, Issue 1, 2026.
Background Emerging evidence indicates that certain chemotherapeutic agents, particularly the bleomycin, etoposide, and cisplatin (BEP) regimen, exert deleterious effects on male reproductive function, including impaired spermatogenesis. Previous studies have demonstrated that Garcinia kola (GK) seed extract and its bioactive biflavonoid constituent ...
O. A. Ayedogba, O. E. Olorundare, A. A. Adeneye, A. M. Ajayi, Y. C. F. Teles, A. A. Fatokun, Sunny Okechukwu Abarikwu   +6 more
wiley   +1 more source

Nanocrystal Formulation to Enhance Oral Absorption of Silybin: Preparation, In Vitro Evaluations, and Pharmacokinetic Evaluations in Rats and Healthy Human Subjects

Pharmaceutics
Despite the various therapeutic benefits and high tolerance of orally administered silybin, poor water-solubility can be the main restrictive physicochemical feature, which results in low oral bioavailability in the absorption. A milk thistle nanocrystal
SeungRee Seo, Gwan-Young Kim, Min-Hwan Kim, Kyung Won Lee, Min-Jae Kim, Mansingh Chaudhary, Khadka Bikram, Taeheon Kim, Seungmok Choi, Heejin Yang, Joo Won Park, Dae-Duk Kim, Ki-Taek Kim   +12 more
doaj   +1 more source

Silymarin Reduces the Inflammatory Response and the Burden of Mycobacterium tuberculosis H37Ra Infection in Human Lung A549 Cells

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Silymarin is a natural polyphenol known for its broad range of biological effects, and research conducted in macrophages and mice infected with Mycobacterium tuberculosis have highlighted its potential as a complementary treatment for tuberculosis. Silymarin modulates multiple cellular signaling pathways associated with various aspects of the immune ...
Norma L. Hernández-Magaña, Olga N. Hernandez De La Cruz, Mauricio Castañón-Arreola, Bassem Refaat   +3 more
wiley   +1 more source

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects [PDF]

, 2015
Chronic liver dysfunction or injury is a serious health problem worldwide. Chronic liver disease involves a wide range of liver pathologies that include fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.
Feng, Y, HONG, M, LI, S, TAN, HY, Tsao, GSW, Wang, N   +5 more
core   +2 more sources

Inhaling Eugenol Inhibits NAFLD by Activating the Hepatic Ectopic Olfactory Receptor Olfr544 and Modulating the Gut Microbiota

Advanced Science, Volume 12, Issue 42, November 13, 2025.
A natural compound from the Chinese medicinal plant Syzygium aromaticum, eugenol, inhaling which can counteract NAFLD by activating the hepatic olfactory receptor olfr544 and enriching Lactobacillus sp. to promoting fat oxidation, catabolism and inhibit lipid synthesis, respectively.
Xiao‐Ran Wang, Zhan‐Zhan Li, Shu‐Ding Sun, Ya‐Gang Song, Jin‐Xin Miao, Xiang‐Xiang Wu, Yong‐Li Han, Xiao‐Lei Zhang, Wen‐Jing Chen, Qing‐Hua Wang, Yu Zhang, Yiping Fu, Yu‐ting Liu, Lin‐yan Lang, Wen‐Xia Zhao, Ming‐San Miao   +15 more
wiley   +1 more source

In vitro cultures of Silybum marianum and silymarin accumulation [PDF]

, 2011
In this study, a protocol for initiation of callus and shoot cultures from leaves and shoot tips explants of different silybium genotypes collected from different locations in Egypt was established. Callus cultures were initiated from leaves explants and
Heywood, Hammouda, Luper, Cacho, Alikaridis, Iqbal, Murashige, Snedecor, Hammoda, Laemmli, Bekheet, Ultrika, Hendriks, Metry, Dörnenburg, Chaturvedi   +15 more
core   +1 more source

Silymarin and diabetic nephropathy. [PDF]

, 2012
Nephropathy is one of the most important complications of diabetes mellitus and drug induced toxicity. Nephrotoxicity is mostly related to oxidative stress and nowadays much attention has been made towards the possible kidney protective properties of ...
Nasri, Hamid., Rafieian-Kopaei, Mahmoud.
core   +1 more source

Nutrigenomic activity of plant derived compounds in health and disease: Results of a dietary intervention study in dog [PDF]

, 2016
The study was conducted to investigate the effects of dietary administrations of four nutraceuticals in dogs. Seventy four dogswere enrolled in the trials, 24 healthy dogs were fedwith a control diet (CT) and the experimental groups received for 60 days ...
Colitti, Monica, Sandri, Misa, Sgorlon, Sandy, Stefanon, Bruno   +3 more
core   +1 more source