Results 71 to 80 of about 5,855 (222)

New 23-phosphodiester derivatives of Silibin and DHS: synthesis and preliminary evaluation of antioxidant properties [PDF]

open access: yes, 2011
Silybin is the major flavonolignan of silymarin which is widely used as a natural remedy for the treatment of cirrhosis, chronic hepatitis, and liver diseases associated with alcohol consumption and exposure to environmental toxins.
DE NAPOLI, LORENZO   +6 more
core  

Plant-derived antivirals against hepatitis c virus infection [PDF]

open access: yes, 2018
Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide.
Harris, M   +3 more
core   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian   +8 more
wiley   +1 more source

Isolation of Active Substances from the Seeds of the Milk Thistle Plant (Silybum marianum) and Determination of Antioxidant Activity [PDF]

open access: yes, 2011
Opisana je izolacija silimarina, smjese dobro definiranih flavonolignana, iz sjemena biljke sikavice (Silybum marianum). Silimarin je ekstrahiran acetonom iz deoleinizirana sjemena bez zagrijavanja. Iskorištenje je iznosilo Y = 4,1 %.
D. Gašo-Sokač, S. Kovač, V. Bušić
core   +2 more sources

Hyalohyphomycotic chronic rhinosinusitis caused by Microascus cirrosus in a cat

open access: yesVeterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 13‐year‐old, male, neutered, indoor‐only, domestic long‐haired cat was presented with an 8‐month history of sneezing and a 2‐month history of epistaxis. Computed tomography demonstrated an irregular contrast‐enhancing soft tissue opacity within both nasal cavities and osteolysis of surrounding bony structures.
Leonel Frutuoso   +4 more
wiley   +1 more source

The Effect of Silybin Encapsulated in Nanoparticles on oprM Gene Expression in Drug Resistant Isolates of Pseudomonas Aeruginosa [PDF]

open access: yesMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: Pseudomonas aeruginosa is an opportunistic nosocomial pathogen that using several classes of antibiotics to treat has been led to the emergence of multiple drug resistance.
Aref Mohammadipour   +2 more
doaj  

The Effect of Uridine Diphosphate‐Glucuronosyltransferase Inhibition on the Pharmacokinetics of Ecopipam and Its Metabolites

open access: yesClinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Ecopipam, a selective dopamine D1 receptor antagonist in development for Tourette syndrome, is primarily converted by uridine diphosphate‐glucuronosyltransferase (UGT)1A9 to ecopipam glucuronide, with a minor metabolic pathway by cytochrome P450 3A4 forming EBS‐101‐40853 (also referred to as N‐desmethylecopipam or SCH 40853; also ...
Virginia D. Schmith   +3 more
wiley   +1 more source

Milk Thistle’s Secret Weapon: Thromboelastometry Reveals How Silybin Modulates Coagulation in Human Plasma In Vitro

open access: yesApplied Sciences
Background: Silybin, the primary active constituent of the milk thistle extract silymarin, has been historically recognized for its hepatoprotective properties. More recently, its potential effects on blood coagulation have garnered attention, suggesting
Justyna Małkowska   +6 more
doaj   +1 more source

Silybin-Phosphatidylcholine Complex Protects Human Gastric and Liver Cells from Oxidative Stress [PDF]

open access: yes, 2015
Silybin is the main component of silymarin with antioxidant, anti-inflammatory and cytoprotective actions. Our aim was to compare the effect of silybin used as single substance, silybin-phosphatidylcholine complex (SilPho), and derivatives of silybin ...
Caraglia, Michele   +8 more
core  

Natural Sweetener Stevioside‐Based Dissolving Microneedles Solubilize Minoxidil for the Treatment of Androgenic Alopecia

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 2, 14 January 2026.
This study addresses limitations of minoxidil (MXD) in treating androgenetic alopecia by using stevioside (STV) as a solubilizing agent and microneedle (MN) material. STV enhanced MXD's solubility and skin absorption, leading to improved drug delivery and significant hair regrowth in animal models, demonstrating strong potential for AGA treatment ...
Junying Zhang   +7 more
wiley   +1 more source

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