Results 51 to 60 of about 5,855 (222)

Total Synthesis of (+)-Silybin A

Chemical and Pharmaceutical Bulletin
We report the first total synthesis of silybin A (1). Key synthetic steps include the construction of the 1,4-benzodioxane neolignan skeleton, a modified Julia-Kocienski olefination reaction between m-nitrophenyltetrazole sulfone (m-NPT sulfone) 10 and aldehyde 21, the formation of the flavanol lignan skeleton 28 via a quinomethide intermediate under ...
Makoto, Inai, Hiroto, Sagara, Yoshinori, Ueno, Hitoshi, Ouchi, Fumihiko, Yoshimura, Tomohiro, Asakawa, Yoshitaka, Hamashima, Toshiyuki, Kan   +7 more
openaire   +2 more sources

Regioselective Formation of Silybin-23-β-D-Glucoside by Glucosylation of Silybin with Cultured Plant Cells of

Natural Product Communications, 2012
Time course experiment revealed that cultured plant cells of Eucalyptus perriniana regioselectively glucosylated silybin to silybin-23-β-D-glucoside in up to 70% yield.
Kei Shimoda, Hiroya Imai, Tadakatsu Mandai, Hiroki Hamada   +3 more
doaj   +1 more source

Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report [PDF]

, 2015
Mushroom poisonings occur when ingestion of wild mushrooms containing toxins takes place, placing the consumers at life-threatening risk. In the present case report, an unusual multiple poisoning with isoxazoles- and amatoxins-containing mushrooms in a ...
Andrade, Sérgio, Baptista, Paula, Bastos, Maria de Lourdes, Carneiro, Ana Cristina, Carvalho, Félix, Conceição, Filipe, Costa, Ana Elisa, Costa, Vera M., Garcia, Juliana, Paiva, José Artur, Pinho, P. Guedes de   +10 more
core   +1 more source

Synthesis and antioxidant evaluation of novel silybin analogues [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2006
In this work, we evaluated the antioxidant properties of the eight novel silybin analogues for their capacity to scavenge free radicals including superoxide anion radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in vitro. Compound 7d demonstrated an excellent antioxidant effect in scavenging superoxide anion free radical with an IC50 value of
Leixiang, Yang, Jingxu, Gong, Feng, Wang, Yongmin, Zhang, Yanguang, Wang, Xiaojiang, Hao, Xiumei, Wu, Hua, Bai, Joachim, Stöckigt, Yu, Zhao   +9 more
openaire   +2 more sources

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Silybin restores glucose uptake after tumour necrosis factor-alpha and lipopolysaccharide stimulation in 3T3-L1 adipocytes

Adipocyte
Obesity is associated with a low-grade chronic inflammatory process characterized by higher circulating TNFα levels, thus contributing to insulin resistance. This study evaluated the effect of silybin, the main bioactive component of silymarin, which has
Alejandra Butanda-Nuñez, Octavio Rodríguez-Cortés, Espiridión Ramos-Martínez, Marco Antonio Cerbón, Galileo Escobedo, Anahí Chavarría   +5 more
doaj   +1 more source

Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice [PDF]

, 2017
Background: In Chinese folk medicine, Corni fructus (C. fructus) has traditionally been used to improve liver function, although the mechanism underlying its activity remains unclear. The aim of the present study was to evaluate the protective effects of
Alberto C. Dias, Cao YP, Chen Chen, Hai Jiang, Huiting Xue, Jian Wang, Lee NH, Liu HY, Marslin Gregory, Meng Wang, Qiao S, Xiaoying Zhang, Yang JF, Yinku Liang, Yu M, Zhang LT, Zhang YP, Zhihui Jiang, Zhou JH   +18 more
core   +1 more source

Infection with the Neorickettsial Organism Stellantchasmus falcatus Agent in an Arctic Fox (Vulpes lagopus)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 1‐year‐old female‐intact arctic fox (Vulpes lagopus) presented for diarrhea, lethargy, severe thrombocytopenia, and hyperbilirubinemia. Blood film evaluation revealed intracytoplasmic coccoid bacteria within moderate numbers of leukocytes consistent with infection by a rickettsial organism.
Jeremy P. Bessett, Alexis G. Davidson, Alyssa M. Scagnelli, Kristen R. Friedrichs   +3 more
wiley   +1 more source

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease [PDF]

, 2019
The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs.
Antonella Amato, Flavia Mulè, Simona Terzo   +2 more
core   +1 more source

Unlocking the Hepatoprotective Potential of Cyperus rotundus Through Edible Vinegar Processing: A Study on Functional Ingredient Enhancement

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Cyperus rotundus L. (CR) and vinegar‐processed CR (VCR) were compared in mouse models of thioacetamide (TAA)‐induced acute and chronic liver injury. VCR exhibited better hepatoprotective effects than raw CR. Composition analysis revealed 35 components in VCR, among which α‐cyperone was present at higher levels than in raw CR.
Gao Jia‐He, Lin Li‐Ting, Liu Yue‐Han, Wang Fu‐Chao, Liu Jun‐Tong, Gao Tian‐Hui   +5 more
wiley   +1 more source