Levosimendan for patients with severely reduced left ventricular systolic function and/or low cardiac output syndrome undergoing cardiac surgery. a systematic review and meta-analysis [PDF]
, 2017 Background: Previous studies have shown beneficial effects of levosimendan in high-risk patients undergoing cardiac surgery. Two large randomized controlled trials (RCTs), however, showed no advantages of levosimendan.
Arcadipane, Antonio +8 more
core +2 more sources
Role of calcium desensitization in the treatment of myocardial dysfunction after deep hypothermic circulatory arrest [PDF]
, 2013 Introduction Rewarming from deep hypothermic circulatory arrest (DHCA) produces calcium desensitization by troponin I (cTnI) phosphorylation which results in myocardial dysfunction.
Faggian, Giuseppe +9 more
core +3 more sources
BioMed Research International, Volume 2018, Issue 1, 2018., 2018 Background. Recent studies suggest that levosimendan does not provide mortality benefit in patients with low cardiac output syndrome undergoing cardiac surgery. These results conflict with previous findings. The aim of the current study is to assess whether levosimendan reduces postoperative mortality in patients with impaired left ventricular function
Benji Wang +4 more
wiley +1 more source
Digitálicos: los resultados del DIG en el siglo XXI [PDF]
, 2010 After the report that there was no statistical significance in the general mortality of the DIG study, the indication of digoxin in the treatment regimens for congestive heart failure (CHF) drastically decreased.
Helber, Izo, Tucci, Paulo José Ferreira
core +4 more sources
Clinical outcomes associated with catecholamine use in patients diagnosed with Takotsubo cardiomyopathy [PDF]
, 2018 Background: Recent hypotheses have suggested the pathophysiological role of catecholamines in the evolution of the Takotsubo syndrome (TTS). The extent of cardiac and circulatory compromise dictates the use of some form of supportive therapy.
Akin, Ibrahim +9 more
core +1 more source
Vasopressors and Inotropes in Acute Myocardial Infarction Related Cardiogenic Shock: A Systematic Review and Meta-Analysis [PDF]
, 2020 Vasopressors and inotropes are routinely used in acute myocardial infarction (AMI) related cardiogenic shock (CS) to improve hemodynamics. We aimed to investigate the effect of routinely used vasopressor and inotropes on mortality in AMI related CS.
D.M. Ouweneel (Dagmar) +8 more
core +1 more source
Calcium sensitizers: What have we learned over the last 25years? [PDF]
, 2018 K
Papp, Gy. Julius +2 more
core +1 more source
Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts [PDF]
, 2012 Background The authors examined whether milrinone and levosimendan could exert cardiac postconditioning effects in rats under normoglycemia and hyperglycemia, and whether the effects could be mediated by mitochondrial permeability transition pore (mPTP).
Shuhei Matsumoto +6 more
core +2 more sources
The efficacy of simendan in the treatment of acute heart failure and its impact on NT-proBNP.
European review for medical and pharmacological sciences, 2019 Simendan is a calcium sensitizer that enhances myocardial contractility but does not affect ventricular diastole. Simendan also has a vasodilatation effect, which causes coronary artery resistance and venous volume blood vessel relax, thereby improving coronary blood supply.
Li, J. +6 more
openaire +2 more sources