Results 101 to 110 of about 3,797 (192)

A simeprevir-inducible molecular switch for the control of cell and gene therapies. [PDF]

Nat Commun, 2023
Chin SE, Schindler C, Vinall L, Dodd RB, Bamber L, Legg S, Sigurdardottir A, Rees DG, Malcolm TIM, Spratley SJ, Granéli C, Sumner J, Tigue NJ.   +12 more
europepmc   +1 more source

Increasing competition in pharmaceutical tenders: Patents, treatment guidelines, and centralised procurement of Hepatitis C drugs in Brazil. [PDF]

Glob Public Health
Mercadante E.
europepmc   +1 more source

Short-Term Clinical and Immunologic Outcomes Conditional on SVR12 in Hepatitis C Virus-Associated Cryoglobulinemic Vasculitis Treated With Direct-Acting Antivirals: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Boonpheng B, Ungprasert P.
europepmc   +1 more source

Machine Learning and Molecular Modeling for Drug Repurposing Targeting Potential PI3Kα Inhibitors in Post-CoViD-19 Pulmonary Fibrosis. [PDF]

ACS Omega
Dos Santos CR, Camargo PG, Rodrigues CR, Lima CHDS, Albuquerque MG.   +4 more
europepmc   +1 more source

Simeprevir: The First Macrocyclic Drug Elucidated Ab Initio by MicroED

Obtaining single crystal X-ray driffraction (XRD) structures of macrocylcic drugs has proven to be challenging. One of the major bottlenecks is growing sufficiently large crystals needed for XRD.
Bu, Guanhong, Danelius, Emma, Wieske, Lianne, H. E., Gonen, Tamir   +3 more
core  

MicroED as a Powerful Tool for Structure Determination of Macrocyclic Drug Compounds Directly from Their Powder Formulations. [PDF]

ACS Chem Biol, 2023
Danelius E, Bu G, Wieske LHE, Gonen T.
europepmc   +1 more source

Loss of KLF15 expression characterizes proximal tubule injury in cisplatin-induced acute kidney injury: A multi-omics study. [PDF]

Curr Res Toxicol
Chen L, Xie S, Yang H, Liu X, Yang S, Wang D.   +5 more
europepmc   +1 more source

Molecular chameleons adaptability in target binding. [PDF]

Struct Dyn
Bu G, Eriksson M, Rova Danelius E.
europepmc   +1 more source

An eco-friendly chemometrics assisted UV spectrophotometric method for simultaneous determination of sofosbuvir, simeprevir and ledipasvir in pharmaceuticals. [PDF]

BMC Chem
Alshehri A, Alqahtani A, Alsayari A, Almrasy AA.   +3 more
europepmc   +1 more source

Repurposing of approved drugs towards Nipah virus treatment: an in silico docking, molecular dynamics simulation and a MM/GBSA approach. [PDF]

In Silico Pharmacol
Hatimuria M, Vishwakarma J, Takkella D, Chandran CN, Phukan P, Gavvala K, Pabbathi A.   +6 more
europepmc   +1 more source