Results 71 to 80 of about 5,730 (206)

Curing Hepatitis C in Liver Transplant Recipients Is Associated with Changes in Immunosuppressant Use. [PDF]

, 2016
Background and aimsAll-oral interferon-free antivirals are highly effective in treating recurrent hepatitis C (HCV) infection in liver transplant (LT) recipients.
Bau, Sherona, Busuttil, Ronald W, Choi, Gina, Durazo, Francisco, El Kabany, Mohammed, Elashoff, David, Farid, Alexander, Grotts, Jonathan, Han, Steven, Jamal, Naadir, Jimenez, Melissa, Rheem, Justin, Saab, Sammy   +12 more
core   +2 more sources

Unsuccessful Direct Acting Antiviral Hepatitis C Treatment Among People With HIV: Findings From an International Cohort

Liver International, Volume 45, Issue 1, January 2025.
ABSTRACT Background Historically, hepatitis C virus (HCV) was difficult to treat among people with HIV. However, treatment with direct‐acting antivirals (DAAs) results in 90%–95% of people being cured. There is a need to understand why a proportion of people are not cured.
Brendan L. Harney, Rachel Sacks‐Davis, Daniela K. van Santen, Ashleigh C. Stewart, Gail V. Matthews, Joanne M. Carson, Marina B. Klein, Karine Lacombe, Linda Wittkop, Dominque Salmon, Olivier Leleux, Laurence Merchadou, Marc van der Valk, Colette Smit, Maria Prins, Anders Boyd, Juan Berenguer, Inmaculada Jarrin, Andri Rauch, Margaret E. Hellard, Joseph S. Doyle   +20 more
wiley   +1 more source

Simeprevir in combination with pegylated interferon-α and ribavirin in the treatment of naïve patients with genotype 1 chronic hepatitis C

Терапевтический архив, 2014
Triple therapy with pegylated interferon-α, ribavirin, and simeprevir is now optimal among the antiviral treatment options available in the Russian Federation for patients with chronic hepatitis C (CHC), including in the compensated stage of liver ...
É Z Burnevich
doaj  

Sustained Virological Response after 8-Week Treatment of Simeprevir with Peginterferon α-2a plus Ribavirin in a Japanese Female with Hepatitis C Virus Genotype 1b and IL28B Minor Genotype

Case Reports in Gastroenterology, 2015
Direct-acting antivirals with or without peginterferon α (PEG-IFN α) plus ribavirin are now available for the treatment of hepatitis C virus (HCV) infection. Direct-acting antivirals are potent inhibitors of HCV replication, but some of them occasionally
Tatsuo Kanda, Masato Nakamura, Reina Sasaki, Shin Yasui, Shingo Nakamoto, Yuki Haga, Xia Jiang, Shuang Wu, Akinobu Tawada, Makoto Arai, Fumio Imazeki, Osamu Yokosuka   +11 more
doaj   +1 more source

Macrocyclic Inhibitors Targeting the Prime Site of the Fibrinolytic Serine Protease Plasmin

ChemMedChem, Volume 19, Issue 23, December 2, 2024.
New macrocyclic inhibitors addressing the S1 pocket and the prime site of the fibrinolytic serine protease plasmin have been developed. A strong potency was found for compounds containing a substituted biphenylalanine as P1’ residue, some of them already exhibit a certain selectivity as plasmin inhibitors.
Simon J. A. Wiedemeyer, Guojie Wu, Heike Lang‐Henkel, James C Whisstock, Ruby H. P. Law, Torsten Steinmetzer   +5 more
wiley   +1 more source

Cost-effectiveness of narlaprevir in the chronic hepatitis C (genotype 1) therapy in treatment-naïve patients and relapsers

Журнал инфектологии, 2016
In the treatment of chronic hepatitis C (CHC) protease inhibitors (PI) are actively used. The aim of this analysis was to evaluate the cost-effectiveness of narlaprevir and simeprevir in the CHC (genotype 1) therapy in treatment-naïve patients and ...
D. A. Gusev, A. V. Rudakova, A. N. Uskov, L. N. Konovalova, Yu. V. Lobzin   +4 more
doaj  

A hepatitis C-vírus-bázispolimorfizmus jelentősége a kezelésben [PDF]

, 2015
Absztrakt A krónikus C-vírus hepatitis kezelése az elmúlt huszonöt évben igen jelentős fejlődésen ment keresztül.
Tornai, István
core   +1 more source

An Updated Structure of Oxybutynin Hydrochloride

Advanced Science, Volume 11, Issue 40, October 28, 2024.
Oxybutynin (Ditropan) is a widely prescribed muscarinic antagonist for treating the overactive bladder. Previous powder X‐ray diffraction (PXRD) structures has problems like inconsistency with 2D chemical structure and X‐ray‐induced photoreduction. Here microcrystal electron diffraction (MicroED) is used to unveil a definitive and improved 3D structure
Jieye Lin, Guanhong Bu, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source

Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia

Case Reports in Hematology, 2016
Hyperbilirubinemia is an adverse reaction of simeprevir (SMV). The majority of these patients were taking concurrent ribavirin presenting elevated unconjugated hyperbilirubinemia due to hemolysis. However, cases of hepatic failure with elevated bilirubin
Nikolaos Papadopoulos, Melanie Deutsch, Athanasios Georgalas, Helias Poulakidas, Lazaros Karnesis   +4 more
doaj   +1 more source

Sofosbuvir in Combination with Simeprevir +/- Ribavirin in Genotype 4 Hepatitis C Patients with Advanced Fibrosis or Cirrhosis: A Real-World Experience from Belgium.

PLoS ONE, 2017
IntroductionHepatitis C virus (HCV) is a major global health issue and successful treatment has been associated with a reduction of risk of all-cause mortality.
Delphine Degré, Thomas Sersté, Luc Lasser, Jean Delwaide, Peter Starkel, Wim Laleman, Philippe Langlet, Hendrik Reynaert, Stefan Bourgeois, Thomas Vanwolleghem, Sergio Negrin Dastis, Thierry Gustot, Anja Geerts, Christophe Van Steenkiste, Chantal de Galocsy, Antonia Lepida, Hans Orlent, Christophe Moreno   +17 more
doaj   +1 more source