Results 41 to 50 of about 1,956 (160)

Potential of 18F-FDG PET toward personalized radiotherapy or chemoradiotherapy in lung cancer [PDF]

, 2013
Purpose We investigated the metabolic response of lung cancer to radiotherapy or chemoradiotherapy by 18F-FDG PET and its utility in guiding timely supplementary therapy. Methods: Glucose metabolic rate (MRglc) was measured in primary lung cancers during
Ancukiewicz, Marek, Choi, Noah Chan H, Chun, Tristen T., Fidias, Panos M., Fischman, Alan J., Kradin, Richard Lawrence, Lynch, Thomas J., Mathisen, Douglas James, Niemierko, Andrzej   +8 more
core   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

DNA sense-and-respond protein modules for mammalian cells [PDF]

, 2015
We generated synthetic protein components that can detect specific DNA sequences and subsequently trigger a desired intracellular response. These modular sensors exploit the programmability of zinc-finger DNA recognition to drive the intein-mediated ...
A Filipovska, AB Tyszkiewicz, AJ Bogdanove, AJ Keung, AS Khalil, AT Ooi, C Banerjee, DF Selgrade, EC Schwartz, HD Mootz, IH Maxwell, J Dekker, J Koch, J Yu, James J Collins, JJ Lohmueller, JS Kim, LM Cobb, M Elrod-Erickson, M Grohmann, M Nambiar, ML Maeder, MP Zeidler, P Tebas, PM Kane, Q Liu, R Hirata, RJ Knox, S Chong, S Kim, S Nogami, Shimyn Slomovic, T Gaj, T Lion, T Ozawa, T Sonntag, X Huang, Z Xie   +37 more
core   +1 more source

Nuclear Assembly in Giant Unilamellar Vesicles Encapsulating Xenopus Egg Extract

Small, Volume 21, Issue 25, June 26, 2025.
Cell nuclei have been reconstituted in membrane‐less compartments using Xenopus egg extract, but not within lipid bilayer‐enclosed compartments. This study modifies the inverted emulsion method by adding chloroform to the lipid‐dispersed oil and extending lipid monolayer formation at the oil–egg extract interface, enabling the encapsulation of egg ...
Sho Takamori, Hisatoshi Mimura, Toshihisa Osaki, Tomo Kondo, Miyuki Shintomi, Keishi Shintomi, Miho Ohsugi, Shoji Takeuchi   +7 more
wiley   +1 more source

Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9 [PDF]

, 2018
Coeliac disease is an autoimmune disorder triggered in genetically predisposed individuals by the ingestion of gluten proteins from wheat, barley and rye. The a-gliadin gene family of wheat contains four highly stimulatory peptides, of which the 33-mer
Barro, Francisco, Gil Humanes, Javier, Giménez, María J., Ozuna Serafini, Carmen Victoria, Sousa Martín, Carolina, Sánchez León, Susana, Voytas, Daniel F.   +6 more
core   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, Volume 6, Issue 5, May 2025.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Modulation of Autophagy-Like Processes by Tumor Viruses [PDF]

, 2014
Autophagy is an intracellular degradation pathway for long-lived proteins and organelles. This process is activated above basal levels upon cell intrinsic or environmental stress and dysregulation of autophagy has been linked to various human diseases ...
Mack, Hildegard I. D., Munger, Karl
core   +1 more source

Ursodeoxycholic Acid Alleviates Palmitic Acid–Induced Apoptosis in Bovine Mammary Epithelial Cells

Animal Science Journal, Volume 96, Issue 1, January/December 2025.
ABSTRACT This study investigated the protective effects of ursodeoxycholic acid (UDCA) against PA‐induced apoptosis in the MAC‐T bovine mammary epithelial cell (bMEC) line by assessing the level of cell viability, oxidative stress indicators, and expression of endoplasmic reticulum (ER) stress markers.
Md. Rezwanul Habib, Yukako Tokutake, Shinichi Yonekura   +2 more
wiley   +1 more source

Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice [PDF]

, 2012
A hepta-guanidino-β-cyclodextrin (G-CD), its hepta-PEG conjugate (G-CD-PEG), and the corresponding anisamide-terminated PEG conjugate (G-CD-PEG-AA) have been synthesised and compared as delivery vectors for siRNA to prostate cancer cells and tumours in ...
Darcy, Raphael, Desgranges, Stephane, Guo, Jianfeng, O'Driscoll, Caitríona M., Ogier, Julien R.   +4 more
core   +1 more source

Mechanistic Insights Into an Ancient Adenovirus Precursor Protein VII Show Multiple Nuclear Import Receptor Pathways

Traffic, Volume 25, Issue 9, September 2024.
The study explores the nuclear transport mechanism of the precursor protein VII from an ancient siadenovirus that utilizes multiple nuclear localization signals (NLSs) and pathways for nuclear delivery. It identifies two strong NLSs that are key drivers of this process, interacting with specific importins.
Sepehr Nematollahzadeh, Ajani Athukorala, Camilla M. Donnelly, Silvia Pavan, Victoria Atelie‐Djossou, Enzo Di Iorio, Babu Nath, Karla J. Helbig, Brian P. McSharry, Jade K. Forwood, Subir Sarker, Gualtiero Alvisi   +11 more
wiley   +1 more source