Results 61 to 70 of about 2,256,432 (315)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Image Trilateral Filter Based on Local Structure Tensor [PDF]
Jisuanji gongcheng, 2017 The intensity similarity weight function adopted in bilateral filter is subjected to the influence of image noise.Moreover,this filter causes blindness in dealing with image details.To overcome the above drawbacks,this paper proposes a novel trilateral ...
XU Guangyu,LIN Yu’e,SHI Wenbing
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Design methods in the application of fractal geometry in design of women printed fabrics
Journal of Architecture, Art & Humanistic Science, 2018 Design is one of the important activities for which the designer studies many different sciences, artistic and philosophical theories, and the most important stages of design.
Shaimaa Shaker
doaj +1 more source
Geometry of self-similar measures [PDF]
, 1995 Las medidas autosemejantes pueden obtenerse considerando el conjunto autosemejante generado por un sistema de semejanzas 1J.i = {
Manuel Morán Cabré +1 more
openaire +4 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Review article: methods of fractal geometry used in the study of complex geomorphic networks
Acta Universitatis Carolinae Geographica, 2014 Fractal geometry methods allow one to quantitatively describe self-similar or self-affined landscape shapes and facilitate the complex/holistic study of natural objects in various scales.
Michal Kusák
doaj +1 more source
Geometry Sharing Network for 3D Point Cloud Classification and Segmentation [PDF]
AAAI Conference on Artificial Intelligence, 2019 In spite of the recent progresses on classifying 3D point cloud with deep CNNs, large geometric transformations like rotation and translation remain challenging problem and harm the final classification performance.
Mingye Xu, Zhipeng Zhou, Y. Qiao
semanticscholar +1 more source