Results 61 to 70 of about 93,598 (304)

Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity

, 2011
The breast cancer suppressor BRCA2 controls the recombinase RAD51 in the reactions that mediate homologous DNA recombination, an essential cellular process required for the error-free repair of DNA double-stranded breaks.
Rajendra, Eason, Skylaris Chris-Kriton, Cole, Daniel J., Venkitaraman Ashok R., Hardwick, Bryn, Payne, Mike C., Mike C. Payne, McKenzie, Grahame J., Grahame J. McKenzie, Cole Daniel J., Mike C Payne, Hardwick Bryn, McKenzie Grahame J., Bryn Hardwick, Grahame J McKenzie, Ashok R Venkitaraman, Chris-Kriton Skylaris, Daniel J Cole, Ashok R. Venkitaraman, Eeson Rajendra, Roberts-Thomson Meredith, Skylaris, Chris-Kriton, Payne Mike C., Kowalczykowski, Stephen Charles, Venkitaraman, Ashok R., Rajendra Eeson, Roberts-Thomson, Meredith, Daniel J. Cole, Meredith Roberts-Thomson   +28 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

SATIN: a micro and mini satellite mining tool of total genome and coding regions with analysis of perfect repeats polymorphism in coding regions

BMC Bioinformatics
Background Tandem repeats are specific sequences in genomic DNA repeated in tandem that are present in all organisms. Among the subcategories of TRs we have Satellite repeats, that is divided into macrosatellites, minisatellites, and microsatellites ...
Carlos Willian Dias Dantas, Sebastião Rodrigues da Costa Neto, Sandy Ingrid Aguiar Alves, Kenny da Costa Pinheiro, Edian Franklin Franco De Los Santos, Rommel Thiago Jucá Ramos   +5 more
doaj   +1 more source

Bovine proteins containing poly-glutamine repeats are often polymorphic and enriched for components of transcriptional regulatory complexes

, 2010
peer-reviewedBackground: About forty human diseases are caused by repeat instability mutations. A distinct subset of these diseases is the result of extreme expansions of polymorphic trinucleotide repeats; typically CAG repeats encoding poly-glutamine ...
Herman Raadsma, Raadsma Herman, Lynn David J, Hobbs, Matthew, Whan Vicki, McWilliam, Sean, Lynn, David J, Tellam, Ross L, Barendse William, Tellam Ross L, Ross L Tellam, Vicki Whan, McWilliam Sean, Khatkar Mehar, Lutzow Ylva, David J Lynn, William Barendse, Ylva Lutzow, Whan, Vicki, Khatkar, Mehar, Raadsma, Herman, Tellam, Ross L., Ylva Strandberg Lutzow, Barendse, William, Lutzow, Ylva Strandberg, Sean McWilliam, Lynn, David J., Lutzow, Ylva S, Matthew Hobbs, Hobbs Matthew, Mehar Khatkar   +30 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Classification of simple sequence repeats (SSRs) and expressed sequence tag-SSRs (EST-SSRs) repeats.

, 2015
Classification of simple sequence repeats (SSRs) and expressed sequence tag-SSRs (EST-SSRs) repeats.
Jihong Hu (384604), Zhixuan Zhu (384603), Yi Ding (172783), Xiaolei Wang (139592), Weidong Ke (830699), Songtao Gui (830698)   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A fast and cost-effective approach to develop and map EST-SSR markers: oak as a case study [PDF]

, 2010
Background: Expressed Sequence Tags (ESTs) are a source of simple sequence repeats (SSRs) that can be used to develop molecular markers for genetic studies.
Ikaran, Ziortza, Mattioni, Claudia, Herrán, A., Chancerel, Emilie, Fiorella Villani, Antoine de Daruvar, Ueno, Saneyoshi, FRIGERIO, Jean-Marc, Catherine Bodénès, Marcello Cherubini, Guichoux, E., GOICOECHEA, Pablo G, Claudia Mattioni, Frigerio, J.M., Buonamici, Anna, Plomion, Christophe, Emilie Chancerel, Hans-Peter Koelewijn, KOELEWIJN, Hans-Peter, de Daruvar, A., Bodénès, Catherine, Villani, F., Saneyoshi Ueno, Chancerel, E., Villani, Fiorella, Cherubini, M., Durand, Jérôme, DUMOULIN, Pierre-Yves, Buonamici, A., Sebastiani, F., Dumoulin, Pierre Yves, Vendramin, Giovanni, Cherubini, Marcello, Alberto, Florian, de Daruvar, Antoine, Ana Herrán, Koelewijn, H.P., Ziortza Ikaran, Cabané, C., Alberto, F., Cyril Cabané, Pablo G Goicoechea, Koelewijn, Hans Peter, Jérôme Durand, Giovanni Vendramin, Sebastiani, Federico, Goicoechea, P.G., Kremer, A., Florian Alberto, Gailing, Oliver, Dumoulin, P.Y., Anna Buonamici, Guichoux, Erwan, Goicoechea, Pablo G., Ueno, S., Herrán, Ana, Vendramin, Giovanni G., Ikaran, Z., Vendramin, G., Daruvar, A., de, Christophe Plomion, Durand, Jérôme, J., Pierre-Yves Dumoulin, Gailing, O., Jean-Marc Frigerio, Oliver Gailing, Erwan Guichoux, Bodénès, C., Federico Sebastiani, Kremer, Antoine, Mattioni, C., Plomion, C., Antoine Kremer, Cabané, Cyril, Durand, J., Frigerio, Jean Marc   +75 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source