Results 41 to 50 of about 244,423 (295)

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

open access: yesAdvanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du   +10 more
wiley   +1 more source

Utilização do planejamento experimental em rede simplex no estudo de resíduo de rocha ornamental como filler para obtenção de máxima compacidade Use of simplex lattice experimental design in the study of ornamental rock waste as filler to obtain maximum compaction

open access: yesCerâmica, 2011
A utilização de agregados industrializados vem crescendo ao longo dos anos para atender a grande demanda da construção civil devido ao crescimento econômico do país.
A. Z. Destefani, J. N. F. Holanda
doaj   +1 more source

The simplex geometry of graphs

open access: yesJournal of Complex Networks, 2019
AbstractGraphs are a central object of study in various scientific fields, such as discrete mathematics, theoretical computer science and network science. These graphs are typically studied using combinatorial, algebraic or probabilistic methods, each of which highlights the properties of graphs in a unique way.
Karel Devriendt, Piet Van Mieghem
openaire   +3 more sources

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

open access: yesAdvanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long   +12 more
wiley   +1 more source

Improvements of the Hermite-Hadamard inequality for the simplex

open access: yesJournal of Inequalities and Applications, 2017
In this study, the simplex whose vertices are barycenters of the given simplex facets plays an essential role. The article provides an extension of the Hermite-Hadamard inequality from the simplex barycenter to any point of the inscribed simplex except ...
Zlatko Pavić
doaj   +1 more source

A case of hidroacanthoma simplex

open access: yesIndian Journal of Dermatology, 2013
We report a case of hidroacanthoma simplex with giant lesion that was found on the left lumbar part which was treated with surgical excision.
Xinfeng Lu   +5 more
openaire   +3 more sources

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin   +9 more
wiley   +1 more source

Hyperspectral Endmember Extraction Using Spatially Weighted Simplex Strategy

open access: yesRemote Sensing, 2019
Spatial information is increasingly becoming a vital factor in the field of hyperspectral endmember extraction, since it takes into consideration the spatial correlation of pixels, which generally involves jointing spectral information for preprocessing ...
Xiangfei Shen, Wenxing Bao
doaj   +1 more source

Pioneer factors in viral infection

open access: yesFrontiers in Immunology, 2023
Pioneer factors are transcription factors sharing the fascinating ability to bind to compact chromatin and thereby alter its transcriptional fate. Most pioneer factors are known for their importance during embryonic development, for instance, in inducing
Eva Neugebauer   +9 more
doaj   +1 more source

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