Results 41 to 50 of about 167,102 (266)
Pioneer factors in viral infection
Frontiers in Immunology, 2023 Pioneer factors are transcription factors sharing the fascinating ability to bind to compact chromatin and thereby alter its transcriptional fate. Most pioneer factors are known for their importance during embryonic development, for instance, in inducing
Eva Neugebauer +9 more
doaj +1 more source
Botrychium simplex var. simplex E. Hitchc. var. simplex
, 2021 Published as part of Info Flora, 2021,
openaire +2 more sources
Advanced Science, EarlyView.RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu +13 more
wiley +1 more source
EnergiesThe rapid development of renewable energy presents challenges to the security and stability of power systems. Aiming at addressing the power system scheduling problem with load demand and wind power uncertainty, this paper proposes the establishment of ...
Jie Hao, Xiuting Guo, Yan Li, Tao Wu
doaj +1 more source
Intervirology, 1997 CNS infections caused by human herpesvirus 1 and human herpesvirus 2-herpes simplex virus type 1 and herpes simplex virus type 2--are reviewed. The major diseases associated with these viruses are meningitis and encephalitis. Two forms of encephalitis are known, neonatal encephalitis and encephalitis occurring after the neonatal period.
Klapper, P. E., Cleator, G. M.
openaire +4 more sources
Advanced Science, EarlyView.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding +13 more
wiley +1 more source
Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization
Advanced Science, EarlyView.A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley +1 more source
Supramolecular Polymer‐Surfactant Co‐Assemblies for Multivalent HSV‐1 Inhibition
Angewandte Chemie, EarlyView.Non‐covalent co‐assembly of BTA with antiviral surfactants produces ratio‐dependent morphologies. Fibrous supramolecular polymers exhibit superior HSV‐1 inhibition, revealing multivalent fiber‐virus interactions and highlighting supramolecular co‐assemblies as a powerful strategy for functional biomedical nanomaterials with demonstrated tunable ...
Christian Zoister +12 more
wiley +2 more sources
Revista Ingenierías Universidad de Medellín, 2014 En este artículo se presentan los principales resultados de la evaluación que sellevó a cabo relacionada con la implementación del método de optimización PSOde convergencia garantizada en topología alternante con el método simplex, en unprocesador ...
Julián Cote +2 more
doaj