Results 51 to 60 of about 244,423 (295)
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
EnergiesThe rapid development of renewable energy presents challenges to the security and stability of power systems. Aiming at addressing the power system scheduling problem with load demand and wind power uncertainty, this paper proposes the establishment of ...
Jie Hao, Xiuting Guo, Yan Li, Tao Wu
doaj +1 more source
Intervirology, 1997 CNS infections caused by human herpesvirus 1 and human herpesvirus 2-herpes simplex virus type 1 and herpes simplex virus type 2--are reviewed. The major diseases associated with these viruses are meningitis and encephalitis. Two forms of encephalitis are known, neonatal encephalitis and encephalitis occurring after the neonatal period.
Klapper, P. E., Cleator, G. M.
openaire +4 more sources
High performance simplex solver [PDF]
, 2013 The dual simplex method is frequently the most efficient technique for solving linear programming (LP) problems. This thesis describes an efficient implementation of the sequential dual simplex method and the design and development of two parallel dual
Huangfu, Qi
core +3 more sources
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo +10 more
wiley +1 more source
Therapeutic hypothermia for severe adult Herpes simplex virus encephalitis [PDF]
, 2012 Despite antiviral treatment and advances in critical care, the Herpes simplex encephalitis (HSE) still has a poor outcome in a significant portion of patients.
Baršić, Bruno, Kutleša, Marko
core +1 more source
A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior
Advanced Science, EarlyView.Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li +12 more
wiley +1 more source
Advanced Science, EarlyView.Lateral flow assays are evolving into interdisciplinary, system‐level sensing platforms. Recent innovations are deconstructed through coupled phases of mass transfer, reaction, and signal transduction, revealing interdependence across porous materials, interfacial chemistry, nanolabels, readout devices, and data‐enabled analysis.
Yan Pan +6 more
wiley +1 more source
Revista Ingenierías Universidad de Medellín, 2014 En este artículo se presentan los principales resultados de la evaluación que sellevó a cabo relacionada con la implementación del método de optimización PSOde convergencia garantizada en topología alternante con el método simplex, en unprocesador ...
Julián Cote +2 more
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