Results 91 to 100 of about 3,978 (184)

The effect of bed rest, unilateral limb immobilization and head‐down tilt on muscle protein synthesis: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract Muscle disuse leads to muscle atrophy and a decrease in muscle function that is primarily driven by reduced muscle protein synthesis (MPS). The aim of this systematic review and meta‐analysis was to examine the effect of different models of muscle disuse on rates of MPS.
Konstantinos Prokopidis, Paul T. Morgan, Colleen S. Deane, Oliver C. Witard, David D. Church   +4 more
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

Improved biochemical properties of roots of selected economic crops after simulated microgravity impact

Frontiers in Space Technologies
Introduction: Microgravity science involves studies of physical phenomena in which the Earth’s-gravity is significantly decreased, and these have given uniquely-new advancements towards understanding cellular metabolic processes.
Funmilola A. Oluwafemi, Omodele Ibraheem, Afolabi R. Olubiyi   +2 more
doaj   +1 more source

Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans

Experimental Physiology, EarlyView.
Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin, Jean‐Christophe Lagacé, Mathil Ruel, Ahmed Ghachem, Guillaume Léonard, Eleonor Riesco, Mathew Piasecki, Jamie S. McPhee, Isabelle J. Dionne   +8 more
wiley   +1 more source

Microgravity as a Tool to Investigate Cancer Induction in Pleura Mesothelial Cells

Current Issues in Molecular Biology
The present work shows that the exposure of mesothelial cells to simulated microgravity changes their cytoskeleton and adhesion proteins, leading to a cell switch from normal towards tumoral cells.
Valentina Bonetto, Corinna Anais Pagano, Maurizio Sabbatini, Valeria Magnelli, Massimo Donadelli, Emilio Marengo, Maria Angela Masini   +6 more
doaj   +1 more source

To Mars through LEO: How commercial space travel will change exploration‐enabling research

Experimental Physiology, EarlyView.
Christopher Puhl, Michail Magkos
wiley   +1 more source

A computational model for retinal haemodynamics under gravitational and postural variations

The Journal of Physiology, EarlyView.
Abstract figure legend The haemodynamic impact of gravitational and postural changes on the retina, and its relevance to spaceflight associated neuro‐ocular syndrome (SANS), remains incompletely characterized. This study assesses retinal haemodynamics from upright to head‐down tilt using a lumped‐parameter model that dynamically couples intraocular ...
Michele Nigro, Andrea Montanino, Eduardo Soudah   +2 more
wiley   +1 more source

Theoretical Model of Transient Regression of Thermoplastic Materials During Flame Spread: Vaporization; Permanent Mass Loss; Surface Shape

Fire and Materials, Volume 50, Issue 3, Page 227-240, April 2026.
ABSTRACT This article examines a transient, one‐dimensional model of surface regression during opposed flow flame spread over finite thickness, non‐charring thermoplastics. Gas to solid conductive transfer from the flame drives sample heating. The solid degrades into volatile fuel molecules in two stages: (1) the pre‐vaporization heat‐up stage and (2 ...
Indrek S. Wichman, Linwei Mou, Sarzina Hossain, Fletcher J. Miller, Sandra L. Olson   +4 more
wiley   +1 more source

Simulated microgravity attenuates myogenesis and contractile function of 3D engineered skeletal muscle tissues

npj Microgravity
While the effects of microgravity on inducing skeletal muscle atrophy have been extensively studied, the impacts of microgravity on myogenesis and its mechanisms remain unclear. In this study, we developed a microphysiological system of engineered muscle
Zhanping Ren, Eun Hyun Ahn, Minjae Do, Devin B. Mair, Amir Monemianesfahani, Peter H. U. Lee, Deok-Ho Kim   +6 more
doaj   +1 more source

Decoding the space integrome: Personalized countermeasures for a mission to Mars

Experimental Physiology, EarlyView.
Damian M. Bailey
wiley   +1 more source