Results 71 to 80 of about 4,453 (185)

Effects of Simulated Microgravity on Embryonic Stem Cells

PLoS ONE, 2011
There have been many studies on the biological effects of simulated microgravity (SMG) on differentiated cells or adult stem cells. However, there has been no systematic study on the effects of SMG on embryonic stem (ES) cells. In this study, we investigated various effects (including cell proliferation, cell cycle distribution, cell differentiation ...
Yulan Wang, Lili An, Yuanda Jiang, Haiying Hang   +3 more
openaire   +4 more sources

Effects of 14 days of head‐down bed rest with or without exercise, and subsequent recovery on bone turnover, density and structure in older adults

Experimental Physiology, EarlyView.
Abstract Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head‐down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure in older adults. Twenty‐two healthy older adults (55–65 years) completed the HDBR protocol.
Guy Hajj‐Boutros, Andréa Faust, Carmelo Mastrandrea, Vita Sonjak, Dounia Rouabhia, Gustavo Duque, Richard Kremer, Stéphanie Chevalier, Julie Lacombe, Mathieu Ferron, Tyler A. Churchward‐Venne, José A. Morais   +11 more
wiley   +1 more source

Musculoskeletal decay and bone–muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures

Experimental Physiology, EarlyView.
Abstract Older adults experience a markedly increased risk of falls and fractures following hospital discharge, largely due to the rapid musculoskeletal deterioration associated with bed rest. Although age‐related muscle and bone loss typically develops gradually, acute physical inactivity accelerates key biological processes underlying sarcopenia and ...
Julia Margarita Reyes, Guy Hajj‐Boutros, Dounia Rouabhia, José Morais, Felipe Salech, Gustavo Duque   +5 more
wiley   +1 more source

Exercise and physiological monitoring in isolated, confined and extreme environments and space analogues: A scoping review

Experimental Physiology, EarlyView.
Abstract This scoping review synthesized evidence on physical activity/exercise and physiological monitoring in isolated, confined and extreme (ICE) environments, with emphasis on Antarctic missions and space analogues. ICE exposures combine cold stress, confinement, disrupted light–dark cycles and psychosocial strain, which can challenge ...
Gustavo S. O. Lima, Kaline V. F. Dinis, Leonardo P. Silva, Nayanne B. Sousa, Maria Keiliane F. S. Silva, Danilo C. Talhari, Josélia S. Almeida, Michele M. Moraes, Rosa M. E. Arantes, Marcos A. Nascimento, Thiago T. Mendes   +10 more
wiley   +1 more source

Extracellular Vesicles for Space Biomedical Research

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
Microgravity reshapes EV biogenesis and cargo selection, which brings new opportunities for longitudinal liquid‐biopsy readouts of stress and aging‐like trajectories, as well as the regenerative products in spaceflight research. ABSTRACT Extracellular vesicles (EVs) are regulated, information‐rich nanovesicles that reflect aspects of parent‐cell state,
Samantha Ali, Brian I. Molina Diaz, Pei Zhuang, Zachary Greenberg, Ye Zhang, Jeffrey Richards, Danny Carlos, Stefanie Countryman, Christiaan Leeuwenburgh, Luke P. Lee, Mei He   +10 more
wiley   +1 more source

Suboptimal Model Predictive Control With a Computation Governor: Stability, Recursive Feasibility, and Applications to Alternating Direction Method of Multipliers

Optimal Control Applications and Methods, Volume 47, Issue 6, Page 1317-1328, November/December 2026.
Computational governor is shown which simultaneously adjusts the reference and adjusts the constraints. ABSTRACT The paper considers a computational governor strategy to facilitate the implementation of Model Predictive Control (MPC) based on inexact optimization when the time available to compute the solution may be insufficient.
Steven van Leeuwen, Ilya Kolmanovsky
wiley   +1 more source

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, Volume 59, Issue 11, November 2026.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

The role and mechanism of ARRB1 in simulated space radiation and microgravity-induced lung carcinogenesis

npj Microgravity
Microgravity can exacerbate radiation-induced DNA damage response, suggesting that microgravity may increase the risk of tumor initiation and development. However, the specific mechanism is still unclear.
Ying Xu, Yunan Ding, Weiwei Pei, Miaomiao Zhang, Xiaofei Wang, Qi Zeng, Tom K. Hei, Wentao Hu, Guangming Zhou   +8 more
doaj   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, Volume 111, Issue 11, Page 5010-5031, 1 November 2026.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

CeO2 nanomaterial regulates wheat endophytic and rhizospheric bacteria to enhance resistance under simulated microgravity stress

npj Microgravity
Certain nanomaterials, including cerium dioxide nanoparticle (CeO2 NP), have shown potential in modulating plant microbial communities to alleviate stressors like simulated microgravity.
Dengbo Chen, Jingjing Cui, Liting Zhao, Pan Xin, Shaocheng Yan, A. G. Degermendzhi, Yuming Fu, Hong Liu   +7 more
doaj   +1 more source