Results 61 to 70 of about 4,453 (185)

The futuristic manifolds of REM sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since one of its first descriptions 70 years ago, rapid eye movement sleep has continually inspired and excited new generations of sleep researchers. Despite significant advancements in understanding its neurocircuitry, underlying mechanisms and microstates, many questions regarding its function, especially beyond the early neurodevelopment ...
Liborio Parrino, Ivana Rosenzweig
wiley   +1 more source

Simulated microgravity improves maturation of cardiomyocytes derived from human induced pluripotent stem cells

Scientific Reports
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) possess tremendous potential for basic research and translational application. However, these cells structurally and functionally resemble fetal cardiomyocytes, which is a major
Parvin Forghani, Aysha Rashid, Lawrence C. Armand, David Wolfson, Rui Liu, Hee Cheol Cho, Joshua T. Maxwell, Hanjoong Jo, Khalid Salaita, Chunhui Xu   +9 more
doaj   +1 more source

Is sleep affected after microgravity and hypergravity exposure? A pilot study

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep is known to be affected in space travel and in residents of the international space station. But little is known about the direct effects of gravity changes on sleep, if other factors, such as sleep conditions, are kept constant. Here, as a first exploration, we investigated sleep before and after exposure to short bouts of microgravity ...
Barbara Le Roy, Aurore Jouvencel, Anika Friedl‐Werner, Ludmila Renel, Youcef Cherchali, Raouf Osseiran, Ernesto Sanz‐Arigita, Jean‐René Cazalets, Etienne Guillaud, Ellemarije Altena   +9 more
wiley   +1 more source

The effect of bed rest, unilateral limb immobilization and head‐down tilt on muscle protein synthesis: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract Muscle disuse leads to muscle atrophy and a decrease in muscle function that is primarily driven by reduced muscle protein synthesis (MPS). The aim of this systematic review and meta‐analysis was to examine the effect of different models of muscle disuse on rates of MPS.
Konstantinos Prokopidis, Paul T. Morgan, Colleen S. Deane, Oliver C. Witard, David D. Church   +4 more
wiley   +1 more source

Simulated Microgravity Causes Faster Replication During Acute Infection of ME49‐Toxoplasma Gondii and Alterations in Host Cells

FASEB BioAdvances
Spaceflight is important to explore the universe. However, astronauts face many health challenges in space including the increased risk of infection.
Musfika Tasnim Shirin, Takafumi Yamada, Iqra Zafar, Daisuke Kondoh, Hiroki Bochimoto, Hironori Bando, Oluyomi Stephen Adeyemi, Yasuhiro Fukuda, Kentaro Kato   +8 more
doaj   +1 more source

The effects of bed rest on cardiometabolic health: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract Horizontal bed rest (HBR) and head‐down tilt (HDT) are models of physical inactivity. In this systematic review and meta‐analysis, we aimed to quantify changes in cardiometabolic outcomes during HBR and HDT in healthy adults. Following the PRISMA guidelines, we searched PubMed, Scopus, Web of Science and Cochrane Library until 1 October 2025 ...
Konstantinos Prokopidis, Tyler Daubrah‐Scott, Alyssa Varanoske, Jordi Morwani‐Mangnani, David D. Church, Colleen S. Deane, Bethan E. Phillips, Emily J. Arentson‐Lantz   +7 more
wiley   +1 more source

The influence of simulated microgravity on the proteome of Daphnia magna [PDF]

npj Microgravity, 2015
The waterflea Daphnia is an interesting candidate for bioregenerative life support systems (BLSS). These animals are particularly promising because of their central role in the limnic food web and its mode of reproduction. However, the response of Daphnia to altered gravity conditions has to be investigated, especially on the molecular level, to ...
Trotter, Benjamin, Otte, Kathrin A., Schoppmann, Kathrin, Hemmersbach, Ruth, Fröhlich, Thomas, Arnold, Georg J., Laforsch, Christian   +6 more
openaire   +3 more sources

Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation

npj Microgravity, 2021
Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight.
Linda Rubinstein, Ann-Sofie Schreurs, Samantha M. Torres, Sonette Steczina, Moniece G. Lowe, Frederico Kiffer, Antiño R. Allen, April E. Ronca, Marianne B. Sowa, Ruth K. Globus, Candice G. T. Tahimic   +10 more
doaj   +1 more source

Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans

Experimental Physiology, EarlyView.
Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin, Jean‐Christophe Lagacé, Mathil Ruel, Ahmed Ghachem, Guillaume Léonard, Eleonor Riesco, Mathew Piasecki, Jamie S. McPhee, Isabelle J. Dionne   +8 more
wiley   +1 more source

Quantitative MRI changes in neck muscle size and composition following long‐duration spaceflight

Experimental Physiology, EarlyView.
Abstract Long‐duration spaceflight poses several challenges to human health, including muscle loss and fat deposition. To mitigate these effects, exercise countermeasures are prescribed. This study aimed to measure neck muscle size and composition changes with long‐duration spaceflight using quantitative magnetic resonance imaging (MRI) and examine ...
Diana A. Madrid Fuentes, Marina S. Sawires, Leon Lenchik, Janet A. Tooze, Ashley A. Weaver   +4 more
wiley   +1 more source