Results 81 to 90 of about 4,453 (185)

Impact of simulated microgravity on oligodendrocyte development: implications for central nervous system repair.

PLoS ONE, 2013
We have recently established a culture system to study the impact of simulated microgravity on oligodendrocyte progenitor cells (OPCs) development. We subjected mouse and human OPCs to a short exposure of simulated microgravity produced by a 3D-Clinostat
Araceli Espinosa-Jeffrey, Pablo M Paez, Veronica T Cheli, Vilma Spreuer, Ina Wanner, Jean de Vellis   +5 more
doaj   +1 more source

Modelling large scale artery haemodynamics from the heart to the eye in response to simulated microgravity

npj Microgravity
We investigated variations in haemodynamics in response to simulated microgravity across a semi-subject-specific three-dimensional (3D) continuous arterial network connecting the heart to the eye using computational fluid dynamics (CFD) simulations ...
Harrison T. Caddy, Lachlan J. Kelsey, Louis P. Parker, Daniel J. Green, Barry J. Doyle   +4 more
doaj   +1 more source

Simulated microgravity decreases apoptosis in fetal fibroblasts

International Journal of Molecular Medicine, 2012
Space travel is a major challenge for human beings. Especially, the mechanisms through which space conditions might alter animal development have been questioned for a long time. The two major physical stress factors that are of relevance in this context are space radiation and weightlessness.
Michaël, Beck, Kevin, Tabury, Marjan, Moreels, Paul, Jacquet, Patrick, Van Oostveldt, Winnok H, De Vos, Sarah, Baatout   +6 more
openaire   +3 more sources

Effects of simulated microgravity on colorectal cancer organoids growth and drug response

Scientific Reports
Cellular and molecular dynamics of human cells are constantly affected by gravity. Alteration of the gravitational force disturbs the cellular equilibrium, which might modify physiological and molecular characteristics. Nevertheless, biological responses
Soon-Chan Kim, Min Jung Kim, Ji Won Park, Young-Kyoung Shin, Seung-Yong Jeong, Sungwan Kim, Ja-Lok Ku   +6 more
doaj   +1 more source

Simulated Microgravity Causes Delayed Platelet Activation and Downregulates Acid-Sensing Ion Channel 1/2 Protein Expression

Biomedicines
Background: Microgravity is a physical force that affects cellular functions, including gene expression, cellular differentiation, proliferation, and signal transduction. Ion channels play an important role in ionic permeability and cell physiology.
Niharika Bala, Ling Yu, Neil S. Harris, Faisal Mukhtar, Abdel A. Alli   +4 more
doaj   +1 more source

Printing knowledge in microgravity: PULSE and the education needed for space biomedicine

Experimental Physiology, EarlyView.
Sarah Baatout, Michela Candotti, Kevin Tabury, Bjorn Baselet, Damian M. Bailey, Lorenzo Moroni   +5 more
wiley   +1 more source

Multi-Omics Analysis Of Effects Of Simulated Microgravity In Hdpscs

International Dental Journal
Aim or purpose: To investigate the effects of simulated microgravity in human dental pulp stem cells (hDPSCs) . Materials and methods: hDPSCs were isolated from third molars of healthy volunteers aged 19-29 years.
Pengyan Qiao, Chuhua Tang, Jiajing Wang, Yingyu Hu   +3 more
doaj   +1 more source

Exosome-mediated perturbation of the immune-bone metabolism axis: a mechanistic investigation into bone loss in a simulated microgravity environment

Artificial Cells, Nanomedicine, and Biotechnology
Spaceflight-related bone loss represents a critical health concern for astronauts undertaking prolonged space missions. This study investigated the mechanistic role of macrophage-derived exosomes in microgravity-induced bone loss using a simulated ...
Fei Yang, Changshun Chen, Chenghui Yang, Rongjin Chen, Zirui Liu, Lei Wen, Hefang Xiao, Libo Zhou, Bin Geng, Yayi Xia   +9 more
doaj   +1 more source

Improved biochemical properties of roots of selected economic crops after simulated microgravity impact

Frontiers in Space Technologies
Introduction: Microgravity science involves studies of physical phenomena in which the Earth’s-gravity is significantly decreased, and these have given uniquely-new advancements towards understanding cellular metabolic processes.
Funmilola A. Oluwafemi, Omodele Ibraheem, Afolabi R. Olubiyi   +2 more
doaj   +1 more source

Integration of Proteomic and Metabolomic Data Reveals the Lipid Metabolism Disorder in the Liver of Rats Exposed to Simulated Microgravity

Biomolecules
Long-term exposure to microgravity is considered to cause liver lipid accumulation, thereby increasing the risk of non-alcoholic fatty liver disease (NAFLD) among astronauts.
Mengyao Ru, Jun He, Yungang Bai, Kun Zhang, Qianqian Shi, Fang Gao, Yunying Wang, Baoli Li, Lan Shen   +8 more
doaj   +1 more source