Results 71 to 80 of about 3,978 (184)

The role and mechanism of ARRB1 in simulated space radiation and microgravity-induced lung carcinogenesis

npj Microgravity
Microgravity can exacerbate radiation-induced DNA damage response, suggesting that microgravity may increase the risk of tumor initiation and development. However, the specific mechanism is still unclear.
Ying Xu, Yunan Ding, Weiwei Pei, Miaomiao Zhang, Xiaofei Wang, Qi Zeng, Tom K. Hei, Wentao Hu, Guangming Zhou   +8 more
doaj   +1 more source

Microgravity Modulates Effects of Chemotherapeutic Drugs on Cancer Cell Migration

Life, 2020
Microgravity or the condition of apparent weightlessness causes bone, muscular and immune system dysfunctions in astronauts following spaceflights. These organ and system-level dysfunctions correlate with changes induced at the single cell level both by ...
Devika Prasanth, Sindhuja Suresh, Sruti Prathivadhi-Bhayankaram, Michael Mimlitz, Noah Zetocha, Bong Lee, Andrew Ekpenyong   +6 more
doaj   +1 more source

50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper‐buoyancy floatation versus 15 min sitting upright

Experimental Physiology, EarlyView.
Abstract Microgravity is associated with stature increases, back pain and post‐flight intervertebral disc (IVD) herniation. This study aims to determine whether 30 s seated 50% body weight (BW) axial loading is comparable to 15 min sitting upright in 1 g upon changes in stature, anterior lumbar IVD height (via ultrasound), passive vertebral stiffness ...
David Marcos‐Lorenzo, Christina Lysandrou, Laura Sudres, Alfonso Gil‐Martinez, Jaap Swanenburg, James Edward Clark, David Andrew Green   +6 more
wiley   +1 more source

Impact of simulated microgravity on oligodendrocyte development: implications for central nervous system repair.

PLoS ONE, 2013
We have recently established a culture system to study the impact of simulated microgravity on oligodendrocyte progenitor cells (OPCs) development. We subjected mouse and human OPCs to a short exposure of simulated microgravity produced by a 3D-Clinostat
Araceli Espinosa-Jeffrey, Pablo M Paez, Veronica T Cheli, Vilma Spreuer, Ina Wanner, Jean de Vellis   +5 more
doaj   +1 more source

Effects of the angle of head‐down tilt on dynamic cerebral autoregulation during combined exposure to cephalad fluid shift and mild hypercapnia

Experimental Physiology, EarlyView.
Abstract Astronauts experience combined exposure to a cephalad fluid shift and mild hypercapnia during space missions, potentially contributing to health problems. Such combined exposure may weaken dynamic cerebral autoregulation. The magnitude of cephalad fluid shift varies between individuals, and dynamic cerebral autoregulation may be affected more ...
Tomokazu Kato, Yojiro Ogawa, Ken‐ichi Iwasaki   +2 more
wiley   +1 more source

An experimentally informed computational model of neurovestibular adaptation to altered gravity

Experimental Physiology, EarlyView.
Abstract Transitions to altered gravity environments result in acute sensorimotor impairment for astronauts, leading to serious mission and safety risks in the crucial first moments in a new setting. Our understanding of the time course and severity of impairment in the early stages of adaptation remains limited and confounded by unmonitored head ...
Victoria G. Kravets, Torin K. Clark
wiley   +1 more source

Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bed rest

Experimental Physiology, EarlyView.
Abstract A reduction in cerebral blood flow (CBF) has been observed during spaceflight and bed rest. We aimed to examine the magnitude and regional heterogeneity of the decrease in CBF during bed rest compared to posture changes on Earth. Seventeen participants (age, 29 ± 9 years, 7 females) were studied in the upright and supine posture and over 3 ...
Carmen Possnig, Kyohei Marume, Gautam Babu, Sylvan L. J. E. Janssen, Christopher M. Hearon Jr, Katrin A. Dias, Satyam Sarma, Justin S. Lawley, Benjamin D. Levine   +8 more
wiley   +1 more source

Exosome-mediated perturbation of the immune-bone metabolism axis: a mechanistic investigation into bone loss in a simulated microgravity environment

Artificial Cells, Nanomedicine, and Biotechnology
Spaceflight-related bone loss represents a critical health concern for astronauts undertaking prolonged space missions. This study investigated the mechanistic role of macrophage-derived exosomes in microgravity-induced bone loss using a simulated ...
Fei Yang, Changshun Chen, Chenghui Yang, Rongjin Chen, Zirui Liu, Lei Wen, Hefang Xiao, Libo Zhou, Bin Geng, Yayi Xia   +9 more
doaj   +1 more source

Induction of NEDD4 under simulated microgravity

The FASEB Journal, 2008
Vascular endothelial cells are exposed to mechanical forces e.g. wall shear stress, wall tension, and pulsatile stretch, which are modulated by the gravitational field. The effects of microgravity may influence endothelial cell function including protein synthesis and degradation.Therefore, this study was designed to investigate microgravity dependent ...
Katarzyna Fiedorowicz, Luis Da Silva Azevedo, Andreas Zakrzewicz, Axel Radlach Pries   +3 more
openaire   +1 more source

Blood flow restriction: The acute effects of body tilting and reduced gravity analogues on limb occlusion pressure

Experimental Physiology, EarlyView.
Abstract Blood flow restriction (BFR) has been identified as a potential countermeasure to mitigate physiological deconditioning during spaceflight. Guidelines recommend that tourniquet pressure be prescribed relative to limb occlusion pressure (LOP); however, it is unclear whether body tilting or reduced gravity analogues influence LOP.
Patrick Swain, Nick Caplan, Luke Hughes
wiley   +1 more source