Results 51 to 60 of about 4,032,596 (264)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effects of using a cognitive aid on content and feasibility of debriefings of simulated emergencies

GMS Journal for Medical Education, 2021
Background: Adverse events in patient care are often caused by failures in teamwork. Simulation training and its debriefing can contribute to improving teamwork and thus patient care. When conducting debriefings, there are several design factors that can
Freytag, Julia, Stroben, Fabian, Hautz, Wolf E., Penders, Dorothea, Kämmer, Juliane E.   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Patient Experience: The field and future [PDF]

, 2017
In an effort to understand the progress and evolution of the field, a self-examination study has been administered to assess contributions to the core knowledge base in the field and to assess the degree to which articles published in Patient Experience ...
Haun, Courtney N., MPH, Wolf, Jason A, PhD, Silvera, Geoffrey A.   +2 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Patient safety in health care professional educational curricula: examining the learning experience [PDF]

, 2009
This study has investigated the formal and informal ways pre-registration students from four healthcare professions learn about patient safety in order to become safe practitioners.
Steven, Alison, Pearson, Pauline, Dawson, Pam   +2 more
core  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Patient care experiences and perceptions of the patient-provider relationship: A mixed method study [PDF]

, 2014
Improving interpersonal continuity of care—the personal relationship forged between a patient and their primary care provider (PCP) over time—is often considered a goal of primary care.
Farrell, Timothy, MD, Tomoaia-Cotisel, Andrada, MPH, MHA, Magill, Michael K., MD, Tabler, Jennifer, MS, Scammon, Debra L., MS, PhD, Kim, Jaewhan, PhD   +5 more
core   +1 more source

Teaching Critical Thinking in Sport Sociology

Proceedings
Can Chat Generative Pre-Trained Transformer or “ChatGPT” and other Large Language Models (LLMs) be used to create challenging and creative assignments for undergraduate students? This article explores the use of ChatGPT as an interview proxy for students.
Conor Heffernan
doaj   +1 more source

Standardized patients versus simulated patients in medical education: are they the same or different [PDF]

Journal of Emergency Practice and Trauma, 2016
In order to equip medical students with all the necessary skills in dealing with patients to provide optimal treatment, the need for the use of real patients in educational settings has become prominent.
Amin Beigzadeh, Bahareh Bahmanbijari, Elham Sharifpoor, Masoumeh Rahimi   +3 more
doaj   +1 more source