Multiple organ injury in septic rats under weightlessness [PDF]
Frontiers in PhysiologyIntroductionAs human space exploration advances, the risk of infection faced by astronauts has also become apparent. However, the impact of sepsis on the body under weightlessness remains unclear.MethodsA rat model of sepsis under simulated ...
Rui Zhai +10 more
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Effects of real and simulated weightlessness on the cardiac and peripheral vascular functions of humans: A review [PDF]
International Journal of Occupational Medicine and Environmental Health, 2015 Weightlessness is an extreme environment that can cause a series of adaptive changes in the human body. Findings from real and simulated weightlessness indicate altered cardiovascular functions, such as reduction in left ventricular (LV) mass, cardiac ...
Hui Zhu, Hanqing Wang, Zhiqiang Liu
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Protective effects of ginsenosides on macrophages subjected to simulated weightlessness
Digital Chinese Medicine, 2023 Objective: To investigate the evolution of inflammation under conditions and the effects of ginsenosides on macrophages subjected to the simulated weightlessness, with the aim of mitigating the inflammation.
Qin Hu, Qingyan Li
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Simulated weightlessness procedure, head-down bed rest has reversible effects on the metabolism of rhesus macaque [PDF]
Molecular BrainIt is a consensus in the international manned space field that factors such as microgravity during the space flight can cause anxiety, depression and other important brain function abnormalities in astronauts.
Yuting Li +16 more
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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions [PDF]
Neural Regeneration ResearchA microgravity environment has been shown to cause ocular damage and affect visual acuity, but the underlying mechanisms remain unclear. Therefore, we established an animal model of weightlessness via tail suspension to examine the pathological changes ...
Yuxue Mu +9 more
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Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading [PDF]
Frontiers in Physiology, 2019 The hindlimb unloading (HU) model has been used extensively to simulate the cephalad fluid shift and musculoskeletal disuse observed in spaceflight with its application expanding to study immune, cardiovascular and central nervous system responses, among
Candice G. T. Tahimic +18 more
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External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial [PDF]
npj Microgravity, 2023 The exact pathophysiology of the spaceflight-associated neuro-ocular syndrome (SANS) has so far not been completely elucidated. In this study we assessed the effect of acute head-down tilt position on the mean flow of the intra- and extracranial vessels.
Alessa L. Boschert +12 more
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Tapping into rhythm generation circuitry in humans during simulated weightlessness conditions [PDF]
Frontiers in Systems Neuroscience, 2015 An ability to produce rhythmic activity is ubiquitous for locomotor pattern generation and modulation. The role that the rhythmogenesis capacity of the spinal cord plays in injured populations has become an area of interest and systematic investigation ...
Irina eSolopova +5 more
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Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats [PDF]
International Journal of OphthalmologyAIM: To analyze visual dysfunction in rats under simulated weightlessness (SW) by examining trans-laminar cribrosa pressure difference (TLCPD) and neuroimmune responses.
Jin-Shuo Liu +8 more
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Impacts of Simulated Weightlessness by Dry Immersion on Optic Nerve Sheath Diameter and Cerebral Autoregulation [PDF]
Frontiers in Physiology, 2017 Dry immersion (DI) is used to simulate weightlessness. We investigated in healthy volunteers if DI induces changes in ONSD, as a surrogate marker of intracranial pressure (ICP) and how these changes could affect cerebral autoregulation (CA).
Marc Kermorgant +13 more
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