Results 21 to 30 of about 6,694 (292)

lncRNA Ubr5 promotes BMSCs apoptosis and inhibits their proliferation and osteogenic differentiation in weightless bone loss [PDF]

Frontiers in Cell and Developmental Biology
BackgroundWeightless bone loss is a common pathological phenomenon in weightless environments, yet its specific molecular mechanism remain incompletely elucidated.
Dong Wang, Yuan Gao, Yingjun Tan, Na Li, Xi Li, Jiaxiang Li, Yikai Pan, Xingcheng Zhao, Ming Yan, Yongchun Wang   +9 more
doaj   +2 more sources

Protective effects of ginsenosides on macrophages subjected to simulated weightlessness

Digital Chinese Medicine, 2023
Objective: To investigate the evolution of inflammation under conditions and the effects of ginsenosides on macrophages subjected to the simulated weightlessness, with the aim of mitigating the inflammation.
Boye Li, Tian Chen, Enhui Ji, Ying Chen, Qin Hu, Qingyan Li   +5 more
doaj   +1 more source

Simulated microgravity affects carrageenan-induced inflammation process in rats [PDF]

Pharmacia, 2023
Weightlessness significantly impacts physiological systems. In the current study, we investigate the effects of 7 days exposure of rats to simulated microgravity (using a modified rat-modeled random positioning machine, working with four experimental ...
Viktor Yotov, Raina Ardasheva, Anita Mihaylova, Nina Doncheva, Ilia Kostadinov, Valentin Turiyski   +5 more
doaj   +3 more sources

High-Throughput Sequencing Reveals CXCR4 and IGF1 Behave Different Roles in Weightlessness Osteoporosis

Stem Cells International, 2022
Objective. This study is aimed at screening the differential expression profiles of mRNA under weightlessness osteoporosis through high-throughput sequencing technology, as well as investigating the pathogenesis of weightlessness osteoporosis at the ...
Dong Wang, Weihang Li, Ziyi Ding, Quan Shi, Shilei Zhang, Zhuoru Zhang, Zhibin Liu, Xiaocheng Wang, Ming Yan   +8 more
doaj   +1 more source

Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats

Frontiers in Pharmacology, 2023
Microgravity experienced during space flight is known to exert several negative effects on the learning ability and memory of astronauts. Few effective strategies are currently available to counteract these effects.
Ning Jiang, Jingwei Lv, Yiwen Zhang, Xinran Sun, Caihong Yao, Qiong Wang, Qinghu He, Xinmin Liu, Xinmin Liu   +8 more
doaj   +1 more source

Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

Scientific Reports, 2021
To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity.
Dong Liang, Jing Ma, Bo Wei
doaj   +1 more source

Effects of Procyanidine on Rats Treated by Iron Overload under Condition of Simulated Weightlessness(原花青素对模拟失重条件下大鼠体内铁过载的影响) [PDF]

Shipin kexue jishu xuebao, 2015
The study aimed to investigate effects of procyanidine on rats treated by iron overload under the condition of simulated weightlessness. Simulated weightlessness was simulated by hind limb unloading rats, which maintained about -30° head down tilt ...
WANG Aidong(王爱东), CHEN Pu(陈 朴), HUANG Luyao(黄璐瑶), ZANG Jiachen(臧佳辰), ZHAO Guanghua(赵广华)   +4 more
doaj   +1 more source

Biofabrication of in situ Self Assembled 3D Cell Cultures in a Weightlessness Environment Generated using Magnetic Levitation

Scientific Reports, 2018
Magnetic levitation though negative magnetophoresis is a novel technology to simulate weightlessness and has recently found applications in material and biological sciences.
Muge Anil-Inevi, Sena Yaman, Ahu Arslan Yildiz, Gulistan Mese, Ozden Yalcin-Ozuysal, H. Cumhur Tekin, Engin Ozcivici   +6 more
doaj   +1 more source

Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions

Frontiers in Systems Neuroscience, 2015
In spite of the experience gained in human space flight since Yuri Gagarin’s historical flight in 1961, there has yet to be identified a completely effective countermeasure for mitigating the effects of weightlessness on humans. Were astronauts to embark
Gilles eClement, Angie eBukley, William ePaloski   +2 more
doaj   +1 more source

Microgravity and Musculoskeletal Health: What Strategies Should Be Used for a Great Challenge?

Life, 2023
Space colonization represents the most insidious challenge for mankind, as numerous obstacles affect the success of space missions. Specifically, the absence of gravitational forces leads to systemic physiological alterations, with particular emphasis on
Roberto Bonanni, Ida Cariati, Mario Marini, Umberto Tarantino, Virginia Tancredi   +4 more
doaj   +1 more source