Results 21 to 30 of about 1,401,410 (172)

Local mapping of root orientation traits by X-ray micro-CT and 3d image analysis: A study case on carrot seedlings grown in simulated vs real weightlessness

Plant Methods
Background Root phenotyping is particularly challenging because of complexity and inaccessibility of root apparatus. Orientation is one of the most important architectural traits of roots and its characterization is generally addressed using multiple ...
L. Gargiulo, G. Mele, L. G. Izzo, L. E. Romano, G. Aronne   +4 more
doaj   +2 more sources

lncRNA Ubr5 promotes BMSCs apoptosis and inhibits their proliferation and osteogenic differentiation in weightless bone loss [PDF]

Frontiers in Cell and Developmental Biology
BackgroundWeightless bone loss is a common pathological phenomenon in weightless environments, yet its specific molecular mechanism remain incompletely elucidated.
Dong Wang, Yuan Gao, Yingjun Tan, Na Li, Xi Li, Jiaxiang Li, Yikai Pan, Xingcheng Zhao, Ming Yan, Yongchun Wang   +9 more
doaj   +2 more sources

Effects of Ginsenoside Rb1 on the Crosstalk between Intestinal Stem Cells and Microbiota in a Simulated Weightlessness Mouse Model. [PDF]

Int J Mol Sci
Exposure to the space microenvironment has been found to disrupt the homeostasis of intestinal epithelial cells and alter the composition of the microbiota.
Zong B, Wang J, Wang K, Hao J, Han JY, Jin R, Ge Q.   +6 more
europepmc   +2 more sources

SIMULATED WEIGHTLESSNESS LED TO THE TRANSFORMATION OF GLYCOLIPID METABOLISM IN THE LIVERS OF MICE

Revista Brasileira de Medicina do Esporte, 2023
Objectives: The effects of weightlessness on the liver were studied using a tail suspension (TS) male mouse model. Methods: The effects of 0-, 2- and 4-week TS (CON, TS2 and TS4 groups) on glycogen and lipid content, as well as on the molecular processes
Ya-Fei Chen, Xingping Wang, Zhe Wang, Le Chen, Xiwen Liu, Xinxing Song, Jing-Wen Zhang, Chuan-Li Wang, Yang-Yang Guo, Jin-hui Xu   +9 more
semanticscholar   +1 more source

Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats. [PDF]

Biomed Res Int, 2018
The present study aimed to determine how the learning and memory gradually change with the prolonged hindlimb unloading (HU) treatment in rats. Different HU durations (7 d, 14 d, 21 d, and 28 d) in Sprague-Dawley (SD) rats were implemented.
Zhang Y, Wang Q, Chen H, Liu X, Lv K, Wang T, Wang Y, Ji G, Cao H, Kan G, Li Y, Qu L.   +11 more
europepmc   +2 more sources

The effect of Bu Zhong Yi Qi decoction on simulated weightlessness‑induced muscle atrophy and its mechanisms. [PDF]

Mol Med Rep, 2017
Microgravity has been previously demonstrated to induce skeletal muscle atrophy, loss of muscle force and disorders in myogenesis and metabolism. Current pharmacological strategies exhibit poor efficacy.
Zhu M, Liu Z, Gao M, Zhang Y, Li Y, Ling S, Zhang P, Zhao C, Jiang L, Liu Y, Li Q, Li D, Hu S, Li Y.   +13 more
europepmc   +2 more sources

Oral Pyruvate Effects on Dorsal Root Ganglia in Simulated Weightlessness Rats

Journal of Neurology Research, 2022
Background: Long-term microgravity in spaceflight has been demonstrated with induction of multi-organ damage and dysfunction, including the dorsal root ganglia (DRG) injury.
Yuan Li, Heng Zhang, Ning-tao Ren, Chao Chen, Peng Qi, Fang-Qiang Zhou, Geng Cui   +6 more
semanticscholar   +1 more source

Simulated microgravity affects carrageenan-induced inflammation process in rats [PDF]

Pharmacia, 2023
Weightlessness significantly impacts physiological systems. In the current study, we investigate the effects of 7 days exposure of rats to simulated microgravity (using a modified rat-modeled random positioning machine, working with four experimental ...
Viktor Yotov, Raina Ardasheva, Anita Mihaylova, Nina Doncheva, Ilia Kostadinov, Valentin Turiyski   +5 more
doaj   +3 more sources

Effects of real and simulated weightlessness on the cardiac and peripheral vascular functions of humans: A review

International Journal of Occupational Medicine and Environmental Health, 2015
Weightlessness is an extreme environment that can cause a series of adaptive changes in the human body. Findings from real and simulated weightlessness indicate altered cardiovascular functions, such as reduction in left ventricular (LV) mass, cardiac ...
Hui Zhu, Hanqing Wang, Zhiqiang Liu
doaj   +1 more source

Simulated weightlessness affects the expression and activity of neuronal nitric oxide synthase in the rat brain. [PDF]

Oncotarget, 2017
Spaceflight induces pathophysiological alterations in various organs. To study pathophysiological adaptations to weightlessness on the ground, the tail suspension (TS) rat model has been used to simulate the effects of weightlessness.
Yoon N, Na K, Kim HS.
europepmc   +2 more sources