Results 51 to 60 of about 6,077,636 (282)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Correction to: COVID-19 pandemic preparation: using simulation for systems-based learning to prepare the largest healthcare workforce and system in Canada

Advances in Simulation, 2021
An amendment to this paper has been published and can be accessed via the original article.
Mirette Dubé, Alyshah Kaba, Theresa Cronin, Sue Barnes, Tara Fuselli, Vincent Grant   +5 more
doaj   +1 more source

Technological trends in wheeled armoured vehicle from patent analysis

선진국방연구, 2023
This study analyzed the domestic and foreign patent applications and technology trends of wheeled armored vehicles. Patents for wheeled armored vehicles have been steadily filed since 2009. As the technology development of armoured vehicles has achieved
Jina Kwon, Gakgyu Kim, Yongju Cho, Kyoungchan Won   +3 more
doaj   +1 more source

Distributed Hybrid Simulation of the Internet of Things and Smart Territories

, 2017
This paper deals with the use of hybrid simulation to build and compose heterogeneous simulation scenarios that can be proficiently exploited to model and represent the Internet of Things (IoT).
D'Angelo, Gabriele, Ferretti, Stefano, Ghini, Vittorio   +2 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Deconvolution by simulation

, 2007
Given samples (x_1,...,x_m) and (z_1,...,z_n) which we believe are independent realizations of random variables X and Z respectively, where we further believe that Z=X+Y with Y independent of X, the problem is to estimate the distribution of Y.
Mallows, Colin
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Simulation and comparative analysis of waste in concrete slabs [PDF]

, 2014
Construction sector generates significant amounts of waste that affects the environment and obstructs a sustainable development. The horizontal structure (slabs and roofs) is one of the building elements, by its functional requirement (geometry and ...
Almaral Sánchez, Jorge Luis, Arredondo Rea, Susana Paola, Cabrera Covarrubias, Francisca Guadalupe, Gómez Soberón, José Manuel Vicente, Gómez Soberón, Luis Alberto, Gómez Soberón, M. Consolación, Ortega Rastrojo, Marta   +6 more
core  

A comparison of CMB- and HLA-based approaches to type I interoperability reference model problems for COTS-based distributed simulation [PDF]

, 2005
Commercial-off-the-shelf (COTS) simulation packages (CSPs) are software used by many simulation modellers to build and experiment with models of various systems in domains such as manufacturing, health, logistics and commerce.
Ayani, R., Boer, C. A., Cai, W., Fujimoto, R. M., Henrik Ahlander, Hibino, H., Lendermann, P., Meyer, R.A., Navonil Mustafee, Rassul Ayani, Simon J. E. Taylor, Stephen J. Turner, Swain, J. J., Taylor, S. J. E., Taylor, S. J. E., Taylor, S. J. E., Taylor, S. J. E.   +16 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source