Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Simulation of Primordial Black Holes with large negative non-Gaussianity [PDF]
, 2022 Albert Escrivà +3 more
openalex +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A simulation study of a honeybee breeding scheme accounting for polyandry, direct and maternal effects on colony performance [PDF]
, 2021 Tristan Kistler +2 more
openalex +1 more source
DIY: Creating Performance Assessments that Measure Up!
MedEdPORTAL, 2014 Introduction The demand for simulation educators to become involved in high stakes performance assessment is growing rapidly. The ability to construct reliable and valid performance assessments, and to evaluate those already available, is necessary in ...
Ann Willemsen-Dunlap +5 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Shaking Table Test and Numerical Simulation Study on Tunnel-Soil-Bridge Pile Structure Interaction System [PDF]
, 2022 Shasha Lu +4 more
openalex +1 more source
Outreach simulation for system improvement: a novel advocacy and reporting process
Advances in SimulationIntroduction Healthcare simulation programmes measuring their value risk wasting resources in attempts to prove they impact patient outcomes. Simulation is one of many strategies used to enhance healthcare systems, and proving specific correlation with ...
A. St-Onge-St-Hilaire +5 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
The Advocacy-Inquiry Rubric (AIR): a standard to build debriefing and feedback skills
Advances in SimulationBackground Teaching and learning debriefing and feedback skills—especially to a level of mastery—is challenging without an agreed-upon standard. There are a number of rating scales and rubrics to identify and evaluate debriefing and feedback skills that ...
Clément Buléon +9 more
doaj +1 more source