Results 81 to 90 of about 12,432,661 (374)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Research and Realization of the Simulation Test System for Train Control On-board Equipment

机车电传动, 2017
Aiming at the requirement of simulation test to train control on-board equipment, the overall technical scheme and the realization method of the simulation test system for train control on-board equipment were presented by analyzing the running ...
Research and Realization of the Simulation Test System for Train Control On-board Equipment
doaj  

Semantic web service architecture for simulation model reuse [PDF]

, 2007
COTS simulation packages (CSPs) have proved popular in an industrial setting with a number of software vendors. In contrast, options for re-using existing models seem more limited.
Bell, D, de Cesare, S, Lycett, M, Mustafee, N, Taylor, S J E   +4 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Deconvolution by simulation

, 2007
Given samples (x_1,...,x_m) and (z_1,...,z_n) which we believe are independent realizations of random variables X and Z respectively, where we further believe that Z=X+Y with Y independent of X, the problem is to estimate the distribution of Y.
Mallows, Colin
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Promoting leadership and communication skills in emergency medicine residents: the role of High-Fidelity Simulation

Emergency Care Journal
The residency program in Emergency Medicine should include formal training in Non-Technical Skills (NTS). We evaluated the effectiveness of a program based on High-Fidelity Simulation (HFS) to improve the leadership and communication skills of residents
Lorenzo Maiorano, Elisa Capretti, Anna De Paris, Alessio Prota, Elisa Paolucci, Rudy Marchetti, Alessandro Coppa, Caterina Savinelli, Riccardo Pini, Francesca Innocenti   +9 more
doaj   +1 more source

The atomic simulation environment-a Python library for working with atoms.

Journal of Physics: Condensed Matter, 2017
The atomic simulation environment (ASE) is a software package written in the Python programming language with the aim of setting up, steering, and analyzing atomistic simulations. In ASE, tasks are fully scripted in Python.
Ask Hjorth Larsen, Jens Jørgen Mortensen, J. Blomqvist, I. Castelli, R. Christensen, M. Dulak, J. Friis, M. Groves, B. Hammer, Cory Hargus, E. Hermes, P. C. Jennings, Peter Bjerre Jensen, J. Kermode, J. Kitchin, Esben Leonhard Kolsbjerg, J. Kubal, K. Kaasbjerg, S. Lysgaard, Jón Bergmann Maronsson, Tristan Maxson, T. Olsen, L. Pastewka, Andrew A. Peterson, C. Rostgaard, J. Schiøtz, O. Schütt, M. Strange, K. Thygesen, T. Vegge, L. Vilhelmsen, M. Walter, Z. Zeng, K. Jacobsen   +33 more
semanticscholar   +1 more source

A Lightweight Multilevel Markup Language for Connecting Software Requirements and Simulations [PDF]

, 2019
[Context] Simulation is a powerful tool to validate specified requirements especially for complex systems that constantly monitor and react to characteristics of their environment.
B Schünemann, C. Nebut, Elizabeth Bjarnason, Garm Lucassen, J Banks   +4 more
core   +1 more source