Results 71 to 80 of about 2,758,037 (275)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Constraints on the relationship between stellar mass and halo mass at low and high redshift

, 2009
We use a statistical approach to determine the relationship between the stellar masses of galaxies and the masses of the dark matter halos in which they reside.
Andrea V. Macciò, Bell, Benjamin P. Moster, Berlind, Bertschinger, Brown, Bryan, Christian Maulbetsch, Cole, Conroy, Conroy, Drory, Drory, Fall, Frank C. van den Bosch, Kauffmann, Klypin, Kravtsov, Lin, Lin, Ludwig Oser, Marín, Moster, Press, Rachel S. Somerville, Shankar, Spergel, Tasitsiomi, Thorsten Naab, Tinker, White, White, Yan, Yang, Yang, Zehavi, Zehavi, Zehavi, Zheng   +38 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Ample Spectrum Contractions and Related Fixed Point Theorems

Mathematics, 2019
Simulation functions were introduced by Khojasteh et al. as a method to extend several classes of fixed point theorems by a simple condition. After that, many researchers have amplified the knowledge of such kind of contractions in several ways.
Antonio Francisco Roldán López de Hierro, Naseer Shahzad   +1 more
doaj   +1 more source

Cosmic history of integrated galactic stellar initial mass function : a simulation study

, 2015
Theoretical and indirect observational evidences suggest that stellar initial mass function (IMF) increases with redshift. On the other hand star formation rates (SFR) may be as high as 100 $M_{\odot}$ yr$^{-1}$ in star burst galaxies.
Chattopadhyay, Asis Kumar, Chattopadhyay, Tanuka, De, Tuli, Warlu, Bharat   +3 more
core   +1 more source

Simulating the function of sodium/proton antiporters [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Understanding the molecular nature of the function of transporters is of significant interest in view of their biological importance. However, the actual structure–function relationship of transporters is far from being clear. To advance this understanding, we simulated the activity of the Na +
Alhadeff, Raphael, Warshel, Arieh
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Random Best Proximity Points for α-Admissible Mappings via Simulation Functions

Mathematics, 2018
In this paper, we introduce a new concept of random α -proximal admissible and random α - Z -contraction. Then we establish random best proximity point theorems for such mapping in complete separable metric spaces.
Chayut Kongban, Poom Kumam, Juan Martínez-Moreno   +2 more
doaj   +1 more source

Local chain ordering in amorphous polymer melts: Influence of chain stiffness

, 1999
Molecular dynamics simulation of a generic polymer model is applied to study melts of polymers with different types of intrinsic stiffness. Important static observables of the single chain such as gyration radius or persistence length are determined ...
Faller, Roland, Kolb, Alexander, Müller-Plathe, Florian   +2 more
core   +1 more source

Simulation via direct computation of partition functions [PDF]

Physical Review E, 2007
In this paper, we demonstrate the efficiency of simulations via direct computation of the partition function under various macroscopic conditions, such as different temperatures or volumes. The method can compute partition functions by flattening histograms, through the Wang-Landau recursive scheme, outside the energy space.
Zhang, Cheng, Ma, Jianpeng
openaire   +3 more sources