Results 31 to 40 of about 16,427,470 (298)
Agriculture, 2021 This study is focused on the estimation of fuel consumption of the power-shift transmission (PST) tractor based on PTO (power take-off) dynamometer test.
Md. Abu Ayub Siddique +8 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
南方能源建设, 2022 [Introduction] The fuel cell distributed generation technology is an important application direction to adapt to the future development trend of low-carbon, clean and high-efficiency energy.
Zhuoyan LI +3 more
doaj +1 more source
Simulation modelling for immunologists [PDF]
Nature Reviews Immunology, 2019 The immune system is inordinately complex with many interacting components determining overall outcomes. Mathematical and computational modelling provides a useful way in which the various contributions of different immunological components can be probed in an integrated manner.
Andreas Handel +2 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Niraparib PBPK modeling to predict optimal dosage in patients with hepatic impairment
Frontiers in PharmacologyObjectiveTo develop a physiologically based pharmacokinetic (PBPK) model of niraparib, predictive of optimal dosage in patients with hepatic impairment and of key pharmacological factors of toxicity.MethodsA comprehensive systematic literature review was
Anatoly Pokladyuk +7 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Sensors, 2023 The main characteristics of high-efficiency switching-mode solid-state power amplifiers with envelope elimination and restoration (EER) methods depend on all their elements.
Dang Canh Nguyen +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source