Results 31 to 40 of about 4,227,869 (356)

Mathematical modeling in autoimmune diseases: from theory to clinical application

Frontiers in Immunology
The research & development (R&D) of novel therapeutic agents for the treatment of autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies of these conditions.
Yaroslav Ugolkov, Yaroslav Ugolkov, Yaroslav Ugolkov, Antonina Nikitich, Antonina Nikitich, Cristina Leon, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Victor Sokolov, Victor Sokolov, Alina Volkova, Alina Volkova   +14 more
doaj   +1 more source

Avaliação de modelos de estimativa da radiação solar incidente em Cruz das Almas, Bahia Evaluating models for estimation of incoming solar radiation in Cruz das Almas, Bahia, Brazil

Revista Brasileira de Engenharia Agrícola e Ambiental, 2010
Em estudos agroambientais a radiação solar incidente (Rs) é uma das mais importantes variáveis meteorológicas. Na ausência de dados observados de Rs é possível estimá-los mediante modelos.
Valéria P. Borges, Aureo S. de Oliveira, Maurício A. Coelho Filho, Tibério S. M. da Silva, Bruce M. Pamponet   +4 more
doaj   +1 more source

Supply Chain Management and Risk Management in an Environment of Stochastic Uncertainty (Retail)

Risks, 2021
In the context of stochastic uncertainty and the increasing complexity of logistics processes in the retail sector, managers face a problem in obtaining accurate forecasts for the dynamics of changes in key business performance indicators. The purpose of
Sergey A. Lochan, Tatiana P. Rozanova, Valery V. Bezpalov, Dmitry V. Fedyunin   +3 more
doaj   +1 more source

Comparison of daily and sub-daily SWAT models for daily streamflow simulation in the Upper Huai River Basin of China [PDF]

, 2015
Despite the significant role of precipitation in the hydrological cycle, few studies have been conducted to evaluate the impacts of the temporal resolution of rainfall inputs on the performance of SWAT (soil and water assessment tool) models in large ...
He, Yi, Liu, Qun, Luo, Xingzhang, Yang, Xiaoying, Zhang, Xiaoxiang   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Sistemas de drenagem agrícola. Parte I: desenvolvimento do modelo e análise de sensibilidade Agricultural drainage systems. Part I: model development and sensitivity analysis

Revista Brasileira de Engenharia Agrícola e Ambiental, 2001
Este trabalho contempla o desenvolvimento de um modelo computacional, visando suprir as principais lacunas em relação aos modelos existentes, e realizar análise de sensibilidade, objetivando verificar o efeito dos parâmetros de entrada sobre os ...
João C. F. Borges Júnior, Paulo A. Ferreira, Fernando F. Pruski, Aziz G. da Silva Júnior   +3 more
doaj   +1 more source

Simulation of Fuel Consumption Based on Engine Load Level of a 95 kW Partial Power-Shift Transmission Tractor

Agriculture, 2021
This study is focused on the estimation of fuel consumption of the power-shift transmission (PST) tractor based on PTO (power take-off) dynamometer test.
Md. Abu Ayub Siddique, Seung-Min Baek, Seung-Yun Baek, Wan-Soo Kim, Yeon-Soo Kim, Yong-Joo Kim, Dae-Hyun Lee, Kwan-Ho Lee, Joon-Yeal Hwang   +8 more
doaj   +1 more source

A sand wave simulation model [PDF]

, 2003
Sand waves form a prominent regular pattern in the offshore seabeds of sandy shallow seas. A two dimensional vertical (2DV) flow and morphological numerical model describing the behaviour of these sand waves has been developed. The model contains the 2DV
Damme, R.M.J. van, Hulscher, S.J.M.H., Nemeth, A.A.   +2 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Niraparib PBPK modeling to predict optimal dosage in patients with hepatic impairment

Frontiers in Pharmacology
ObjectiveTo develop a physiologically based pharmacokinetic (PBPK) model of niraparib, predictive of optimal dosage in patients with hepatic impairment and of key pharmacological factors of toxicity.MethodsA comprehensive systematic literature review was
Anatoly Pokladyuk, Veronika Voronova, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Yuri Kosinsky   +7 more
doaj   +1 more source