Results 51 to 60 of about 16,427,470 (298)

Quantitative systems pharmacology model of B cell immune response in mouse

Frontiers in Immunology
B cell-mediated immunity plays a crucial role in long-term humoral protection. However, dysregulation of B cell development and differentiation may lead to the persistence of autoreactive clones, contributing to autoimmune diseases.
Yaroslav Ugolkov, Yaroslav Ugolkov, Yaroslav Ugolkov, Alina Volkova, Alina Volkova, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Victor Sokolov, Victor Sokolov   +10 more
doaj   +1 more source

Development of the Phaseless Calibration Algorithm for a Digital Antenna Array

Inventions, 2023
In this paper, we will discuss a calibration algorithm for a digital antenna array that diagnoses its real performance. It can be applied at such stages of the antenna system life cycle as design, tuning, and especially maintenance.
Elena Dobychina, Mikhail Snastin, Vladimir Savchenko, Timofey Shevgunov   +3 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Modeling the train operation of the mainline locomotive

Вестник Научно-исследовательского института железнодорожного транспорта, 2018
To date, there is a large number of programs that simulate the train operation of the locomotive using the method of traction calculations. As input data in the program, information is entered about the track section, locomotive and train composition ...
A. G. Silyuta, E. E. Kossov
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Experimental and Theoretical Investigations of the Mechanical Behavior of Column-Free Quasi-Rectangular Segmental Tunnel Linings

Applied Sciences
To investigate the mechanical behavior and design methodology of column-free QRST (quasi-rectangular segmental tunnel) structures, a theoretical analysis based on prototype experiments and simulation models is conducted.
Zhen Liu, Yizheng Chen, Yuebin Wu, Xian Liu   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Methodologies for data collection and model documentation in computer simulation [PDF]

, 2005
In recent years, computer simulation has become a mainstream decision support tool in an industry. In order to maximise the benefits of using simulation within businesses, simulation models should be designed, developed and deployed in a shorter time ...
Liyanage, Kapila
core  

Independent verification and validation of an industrial simulation model [PDF]

, 2010
The independent verification and validation (IV&V) of simulation models is largely restricted to applications in the military and public policy domains. There is little evidence of IV&V for industrial simulation models. This is largely because industrial
Brooks RJ, Robinson, Stewart, Brooks, Roger J., Robinson S   +3 more
core   +1 more source