Results 61 to 70 of about 16,427,470 (298)
CPT: Pharmacometrics & Systems PharmacologyGastrointestinal first‐pass metabolism plays an important role in bioavailability and in drug–drug interactions. Physiologically‐based pharmacokinetic (PBPK) modeling is a powerful tool to integrate these processes mechanistically.
Justine Henriot +4 more
doaj +1 more source
Enhanced Buck Converter with Universal Model for the Switched Voltage Regulators
CommunicationsThis article presents the enhancement and refinement of a simulation model for an integrated universal switched voltage regulator compatible with PSPICE software.
Dobroslav Kováč, Irena Kováčová
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A ducted wind turbine simulation model for building simulation [PDF]
, 2004 Power production is shifting away from centralized generation plants to production of heat and power at the point of demand. A technology that may play a part in this shift is the ducted wind turbine (DWT).
Kelly, N.J., Grant, A.D.
core +3 more sources
Assessing the Risks of a Freight Forwarder Entering the Transport Market with Stochastic Demand
CommunicationsThis research investigates freight forwarders' operational risks when entering a new transport market characterized by stochastic demand. A simulation model was developed to represent the service request flow potentially experienced by a freight ...
Vitalii Naumov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Analysis and Simulation of SIRI Model for Dengue Fever Transmission [PDF]
, 2020 Objectives: The aim of this study is to obtain SIRI model for dengue fever (DHF) transmission, conduct analysis, and simulation of SIRI model in disease-free and endemic and also to predict the number of DHF cases.
Side, Syafruddin +3 more
core
Model-based, composable simulation for the development of autonomous miniature vehicles
, 2013 Modern vehicles contain nearly 100 embedded control units to realize various comfort and safety functions. These vehicle functions consist of a sensor, a data processing, and an actor layer to react intelligently to stimuli from their context.
Berger, Christian +4 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source