Results 41 to 50 of about 4,227,869 (356)

Modeling and Simulation Analysis of MW-Level Fuel Cell Distributed Generation System Based on AspenPlus

南方能源建设, 2022
[Introduction] The fuel cell distributed generation technology is an important application direction to adapt to the future development trend of low-carbon, clean and high-efficiency energy.
Zhuoyan LI, Liping DUAN, Shaohua LI, Jing FENG   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Cosmological Simulation for Fuzzy Dark Matter Model

, 2019
Fuzzy Dark Matter (FDM), motivated by string theory, has recently become a hot candidate for dark matter. The rest mass of FDM is believed to be $\sim 10^{-22}$eV and the corresponding de-Broglie wave length is $\sim 1$kpc.
Chu, Ming-Chung, Liu, Hantao, Zhang, Jiajun   +2 more
core   +1 more source

A cross‐faculty simulation model for authentic learning [PDF]

, 2011
This paper proposes a cross‐faculty simulation model for authentic learning that bridges the gap between short group‐based simulations within the classroom and longer individual placements in professional working contexts.
Andrew Middleton, Harvey L., Herrington J., Kemmis S., Newmann F., Richard Mather, Rule A., Susannah Diamond, Van Ments M., Vincent A.   +9 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Harnessing Open‐Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference

CPT: Pharmacometrics & Systems Pharmacology
In 2017, the free and open‐source software Open Systems Pharmacology (OSP) was launched. Since then, OSP has evolved from a small community into a diverse network of stakeholders committed to advancing open‐source solutions for model‐informed drug ...
André Dallmann, Denise Feick, Pavel Balazki, Salih Benamara, Rolf Burghaus, Marylore Chenel, Siak‐Leng Choi, Henrik Cordes, Mariana Guimarães, Abdullah Hamadeh, Ibrahim Ince, Kathleen M. Job, Tobias Kanacher, Andreas Kovar, Lars Kuepfer, Jörg Lippert, Julia Macente, Nina Nauwelaerts, Christoph Niederalt, Sheila Peters, Susana Proença, Masanobu Sato, Stephan Schaller, Jan Frederik Schlender, Annika Schneider, Erik Sjögren, Juri Solodenko, Alexander Staab, Paul Vrenken, Thomas Wendl, Wilhelmus E. A. deWitte, Donato Teutonico   +31 more
doaj   +1 more source

Theoretical Comparison of Different Envelope Elimination and Restoration Transmitter PWM Modulator Configurations to Expand the Possible Antenna Mismatch

Sensors, 2023
The main characteristics of high-efficiency switching-mode solid-state power amplifiers with envelope elimination and restoration (EER) methods depend on all their elements.
Dang Canh Nguyen, Victor N. Gromorushkin, Oleg Varlamov   +2 more
doaj   +1 more source

Towards a unified conceptual model representation [PDF]

, 2007
A good documentation or representation is important for communicating simulation conceptual models between stakeholders effectively. A good conceptual model representation may be used as a legal document in a simulation project contract; it may be used ...
Onggo, B S S
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source