Results 61 to 70 of about 81,406 (219)

Software for Explicitly Parallel Memory-Centric Processor Architect

open access: yesProceedings of the International Conference on Applied Innovations in IT, 2015
Advances in computer memory technology justify research towards new and different views on computer organization. This paper proposes a novel memory-centric computing architecture with the goal to merge memory and processing elements in order to provide ...
Goce Dokoski   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

A System to Collect and Analyze Data for Problem-solving Challenges Using Computer Games (Example of GT-R: Simulator)

open access: yesСовременные информационные технологии и IT-образование, 2019
The value of data and the importance of interpreting these data is one of the tenets of the digital economy. A variety of data collection sources provides a holistic view of the object and its behavior, but it also creates barriers in creating models ...
Evgeny Egorov   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

One Simulated Hand, Two Real Hands: Antisimulation and Phenomenological Correspondence in Videogame Control Schemes

open access: yesPress Start, 2015
This paper sets out a framework for understanding the control schemes of computer games in terms of ‘phenomenological correspondence’. The complexity of the simulated action corresponds with the complexity of the player’s action on the controls.
Joseph Garvin
doaj  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Development of a Web Application for Simulating Plasma Drug Concentrations in Patients with Zolpidem Intoxication

open access: yesPharmaceutics
Zolpidem is a widely prescribed hypnotic Z-drug used to treat short-term insomnia. However, a growing number of individuals intentionally overdose on these drugs.
Hwa Jun Cha   +3 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

open access: yesFEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli   +3 more
wiley   +1 more source

Modular PEM Fuel Cell SCADA & Simulator System

open access: yesResources, 2015
The paper presents a Supervision, Control, Data Acquisition and Simulation (SCADA & Simulator) system that allows for real-time training in the actual operation of a modular PEM fuel cell system.
Francisca Segura, José Manuel Andújar
doaj   +1 more source

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