Results 41 to 50 of about 25,278 (267)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Features of Simulation-Based Educational Programs: Example of Transport Education and Training
Современные информационные технологии и IT-образование, 2019 The introduction of high technology results in growing demand for practical skills that constitute inherent part of employees’ qualifications acquired through on-the-job training as well as during education period.
Alexander A. Klimov +2 more
doaj +1 more source
Development of a Simulator for Prototyping Reinforcement Learning-Based Autonomous Cars
Informatics, 2022 Autonomous driving is a research field that has received attention in recent years, with increasing applications of reinforcement learning (RL) algorithms.
Martin Holen +2 more
doaj +1 more source
To Simulate or Not to Simulate: What Are the Questions? [PDF]
Neuron, 2014 Simulation is a powerful method in science and engineering. However, simulation is an umbrella term, and its meaning and goals differ among disciplines. Rapid advances in neuroscience and computing draw increasing attention to large-scale brain simulations. What is the meaning of simulation, and what should the method expect to achieve?
Dudai, Yadin, Evers, Kathinka
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Human factor in a safety problem of high-duty welded objects
Advanced Engineering Research, 2016 The work goal is to study the human factor role in a safety problem of the ultrasonic testing of high-duty welded objects. The key objective and subjective factors determining the human reliability of the man-machine systems are analyzed.
Alexander S. Korobtsov +1 more
doaj +1 more source
Theoretical Computer Science, 2010 Boolean notions of correctness are formalized by preorders on systems. Quantitative measures of correctness can be formalized by real-valued distance functions between systems, where the distance between implementation and specification provides a measure of “fit” or “desirability.” We extend the simulation preorder to the quantitative setting, by ...
Cerný +3 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Medical VR Simulator for Pediatric Strabismus Treatment
TechnologiesIn the process of treating pediatric strabismus, great difficulties arise with maintaining attention and a high level of motivation in patients. Existing computer programs and medical equipment should be supplemented with more modern tools and approaches
Artem Obukhov +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source