Results 51 to 60 of about 25,278 (267)

Low Pressure Tube Transport—An Alternative to Ground Road Transport—Aerodynamic and Other Problems and Possible Solutions

Energies, 2021
This paper presents the concept of one possible but unconventional implementation of a Low Pressure Tube Transport (LPTT) system for a network with station-to-station distances of 300 km, based on the use of circular tunnels in which modular vehicles ...
Janusz Piechna
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Simulations in coalgebra

Theoretical Computer Science, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jacobs, B.P.F., Hughes, J.
openaire   +4 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Racer’s Brain – How Domain Expertise is Reflected in the Neural Substrates of Driving

Frontiers in Human Neuroscience, 2015
A fundamental question in human brain plasticity is how sensory, motor, and cognitive functions adapt in the process of skill acquisition extended over a period of many years.
Otto eLappi
doaj   +1 more source

Quantifying Long-Term Bird Population Responses to Simulated Harvest Plans and Cumulative Effects of Disturbance

Frontiers in Ecology and Evolution, 2020
There is interest in linking outputs from land use simulators to bird species distribution models to project how boreal birds will respond to cumulative effects of caribou (Rangifer tarandus) conservation, harvest, fire, and energy-sector development in ...
Lionel Leston, Erin Bayne, Elston Dzus, Péter Sólymos, Tom Moore, David Andison, Dave Cheyne, Matt Carlson   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparative performance of high-fidelity training models for flexible ureteroscopy: Are all models effective?

Indian Journal of Urology, 2011
Objective: We performed a comparative study of high-fidelity training models for flexible ureteroscopy (URS). Our objective was to determine whether high-fidelity non-virtual reality (VR) models are as effective as the VR model in teaching flexible URS ...
Shashikant Mishra, Rajan Sharma, Akhilesh Kumar, Pradeep Ganatra, Ravindra B Sabnis, Mahesh R Desai   +5 more
doaj   +1 more source

Computer Simulation for the Process of Overlapping Solid Sets of Sprinkler Irrigation Using Single Sprinkler Data. [PDF]

Kirkuk Journal of Science, 2018
This study includes the preparation of a computer program for working the overlapping of sprinklers using the Fortran Programing where the program deal with one sprinkler data in the field and convert this data to four sprinklers working together in the ...
Abdulrazaq Abdulwahd
doaj   +1 more source