Results 11 to 20 of about 990,428 (260)

Clinical Perspectives of Single-Cell RNA Sequencing

Biomolecules, 2021
The ability of single-cell genomics to resolve cellular heterogeneity is highly appreciated in cancer and is being exploited for precision medicine. In the recent decade, we have witnessed the incorporation of cancer genomics into the clinical decision ...
Nayoung Kim, Hye Hyeon Eum, Hae-Ock Lee
doaj   +1 more source

scDA: Single cell discriminant analysis for single-cell RNA sequencing data

Computational and Structural Biotechnology Journal, 2021
Single-cell RNA-sequencing (scRNA-seq) techniques provide unprecedented opportunities to investigate phenotypic and molecular heterogeneity in complex biological systems.
Qianqian Shi, Xinxing Li, Qirui Peng, Chuanchao Zhang, Luonan Chen   +4 more
doaj   +1 more source

Single-cell RNA sequencing in orthopedic research

Bone Research, 2023
Although previous RNA sequencing methods have been widely used in orthopedic research and have provided ideas for therapeutic strategies, the specific mechanisms of some orthopedic disorders, including osteoarthritis, lumbar disc herniation, rheumatoid ...
Tao Wang, Ling Wang, Liping Zhang, Yubin Long, Yingze Zhang, Zhiyong Hou   +5 more
doaj   +1 more source

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]

, 2017
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J, Durinck, Steffen, Friedman, Brad A, Ha, Connie, Liu, Jinfeng, Modrusan, Zora, Rubenstein, John L, Seshagiri, Somasekar   +7 more
core   +1 more source

Delineating COVID-19 immunological features using single-cell RNA sequencing

The Innovation, 2022
Understanding the molecular mechanisms of coronavirus disease 2019 (COVID-19) pathogenesis and immune response is vital for developing therapies. Single-cell RNA sequencing has been applied to delineate the cellular heterogeneity of the host response ...
Wendao Liu, Johnathan Jia, Yulin Dai, Wenhao Chen, Guangsheng Pei, Qiheng Yan, Zhongming Zhao   +6 more
doaj   +1 more source

Single Cell RNA Sequencing of Rare Immune Cell Populations

Frontiers in Immunology, 2018
Single-cell RNA sequencing (scRNA-Seq) is transforming our ability to characterize cells, particularly rare cells that are often overlooked in bulk population analytical approaches.
Akira Nguyen, Akira Nguyen, Weng Hua Khoo, Weng Hua Khoo, Imogen Moran, Imogen Moran, Peter I. Croucher, Peter I. Croucher, Tri Giang Phan, Tri Giang Phan   +9 more
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The Application of Single-Cell RNA Sequencing in Vaccinology

Journal of Immunology Research, 2020
Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher
Andrés Noé, Tamsin N. Cargill, Carolyn M. Nielsen, Andrew J. C. Russell, Eleanor Barnes   +4 more
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Normalizing single-cell RNA sequencing data: challenges and opportunities [PDF]

, 2017
Single-cell transcriptomics is becoming an important component of the molecular biologist's toolkit. A critical step when analyzing data generated using this technology is normalization.
A Mortazavi, A Scialdone, A Zeisel, A-E Saliba, AA Kolodziejczyk, AA Kolodziejczyk, AA Pollen, AM Klein, Antonio Scialdone, AT Lun, B Ding, B Li, C Gawad, C Trapnell, CA Vallejos, CA Vallejos, Catalina A Vallejos, D Grün, D Risso, Davide Risso, E Pierson, E Shapiro, EZ Macosko, F Buettner, F Tang, G Finak, GK Smyth, J Lovén, JH Bullard, John C Marioni, JT Leek, L Haghverdi, L Jiang, M Goolam, M-A Dillies, MD Robinson, O Stegle, P Brennecke, PV Kharchenko, R Bacher, S Anders, S Islam, S Islam, S Katayama, SA Hardwick, SA Munro, Sandrine Dudoit, X Qiu   +47 more
core   +2 more sources

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy [PDF]

, 2020
Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly ...
Adair, Jennifer E., DeBerg, Hannah A., Enstrom, Mark R., Gersuk, Vivian, Gottardo, Raphaël, Hanafi, Laïla-Aïcha, Hawkins, Reed, Kiem, Hans-Peter, Linsley, Peter S., Maloney, David G., Pande, Dnyanada, Riddell, Stanley R., Sheih, Alyssa, Turtle, Cameron J., Voillet, Valentin, Wohlfahrt, Martin E., Yajima, Masanao   +16 more
core   +1 more source

Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell Technologies

Frontiers in Synaptic Neuroscience, 2021
Microglia are resident immune cells in the central nervous system and play critical roles in brain immunity, development, and homeostasis. The pathology of Alzheimer’s disease (AD) triggers activation of microglia.
Hansen Wang
doaj   +1 more source