Results 31 to 40 of about 990,428 (260)

Single-cell RNA-sequencing of the brain

Clinical and Translational Medicine, 2017
Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs.
Raquel Cuevas-Diaz Duran, Haichao Wei, Jia Qian Wu   +2 more
doaj   +1 more source

Bulk RNA-seq and scRNA-seq analysis reveal an activation of immune response and compromise of secretory function in major salivary glands of obese mice

Computational and Structural Biotechnology Journal, 2023
Obesity affects the function of multiple organs/tissues including the exocrine organ salivary glands. However, the effects of obesity on transcriptomes and cell compositions in the salivary glands have yet been studied by bulk RNA-sequencing and single ...
Heping Huang, Ce Gao, Shuai Wang, Fen Wu, Jinsong Wei, Jinrong Peng   +5 more
doaj   +1 more source

Meta-analysis of honey bee neurogenomic response links deformed wing virus type A to precocious behavioral maturation [PDF]

, 2020
Crop pollination by the western honey bee Apis mellifera is vital to agriculture but threatened by alarmingly high levels of colony mortality, especially in Europe and North America.
Ahmed, Amy Cash, Bukhari, Syed Abbas, Hamilton, Adam R., Kevill, Jessica, Naeger, Nicholas L., Robinson, Gene E., Schroeder, Declan C., Traniello, Ian M.   +7 more
core   +1 more source

From bulk, single-cell to spatial RNA sequencing

International Journal of Oral Science, 2021
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing.
Xinmin Li, Cun-Yu Wang
doaj   +1 more source

Continual learning approaches for single cell RNA sequencing data

Scientific Reports, 2023
Single-cell RNA sequencing data is among the most interesting and impactful data of today and the sizes of the available datasets are increasing drastically.
Gorkem Saygili, Busra OzgodeYigin
doaj   +1 more source

Inferring spatial and signaling relationships between cells from single cell transcriptomic data. [PDF]

, 2020
Single-cell RNA sequencing (scRNA-seq) provides details for individual cells; however, crucial spatial information is often lost. We present SpaOTsc, a method relying on structured optimal transport to recover spatial properties of scRNA-seq data by ...
Cang, Zixuan, Nie, Qing
core  

Comprehensive profiling of rhizome-associated alternative splicing and alternative polyadenylation in moso bamboo (Phyllostachys edulis). [PDF]

, 2017
Moso bamboo (Phyllostachys edulis) represents one of the fastest-spreading plants in the world, due in part to its well-developed rhizome system. However, the post-transcriptional mechanism for the development of the rhizome system in bamboo has not been
Cai, Dawei, Gao, Yubang, Gu, Lianfeng, Lin, Chentao, Ma, Liuyin, Wang, Huiyuan, Wang, Taotao, Wang, Yongsheng, Zhang, Hangxiao   +8 more
core   +1 more source

Large-scale and significant expression from pseudogenes in Sodalis glossinidius – a facultative bacterial endosymbiont [PDF]

, 2020
The majority of bacterial genomes have high coding efficiencies, but there are some genomes of intracellular bacteria that have low gene density. The genome of the endosymbiont Sodalis glossinidius contains almost 50 % pseudogenes containing mutations ...
Beynon, R, Blow, F, Brownridge, P, Darby, AC, Goodhead, IB, Hughes, M, Kenny, J, Krishna, R, McLean, L, Pongchaikul, P   +9 more
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Single-Cell RNA-Sequencing: Assessment of Differential Expression Analysis Methods

Frontiers in Genetics, 2017
The sequencing of the transcriptomes of single-cells, or single-cell RNA-sequencing, has now become the dominant technology for the identification of novel cell types and for the study of stochastic gene expression.
Alessandra Dal Molin, Giacomo Baruzzo, Barbara Di Camillo   +2 more
doaj   +1 more source