Results 31 to 40 of about 730,650 (264)

Computational analysis of next generation sequencing data : from transcription start sites in bacteria to human non-coding RNAS [PDF]

, 2014
The advent of next generation sequencing (NGS) technologies has revolutionized the field of molecular biology by providing a wealth of sequence data. “Transcriptomics”, which aims to identify and annotate the complete set of RNA molecules transcribed ...
Jorjani, Hadi
core   +1 more source

Nuclear RNA sequencing of the mouse erythroid cell transcriptome

, 2012
Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Umlauf David, Catherine A. Moir (115926), Chakalova, L, Peter Fraser, Eskiw, CH, Mitchell, JA, Fraser, P, Mitchell Jennifer A., Schoenfelder, S, Umlauf, D, Clay Ieuan, Chakalova Lyubomira, David Umlauf (115924), Ieuan Clay, Jennifer A. Mitchell (32136), Schoenfelder Stefan, Chih-Yu Chen, Eskiw Christopher H., Stefan Schoenfelder, Ieuan Clay (115922), Chih-yu Chen (4730856), Fraser Peter, Takashi Nagano, Christopher H. Eskiw (115928), Takashi Nagano (115932), Christopher H Eskiw, Nagano Takashi, Lyubomira Chakalova, Nagano, T, Peter Fraser (32141), Stefan Schoenfelder (115930), Chen, CY, Moir, CA, Lyubomira Chakalova (23035), Chen Chih-yu, Jennifer A Mitchell, Clay, I, David Umlauf, Catherine A Moir, Moir Catherine A.   +39 more
core   +1 more source

Single-cell RNA-sequencing of the brain

Clinical and Translational Medicine, 2017
Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs.
Raquel Cuevas-Diaz Duran, Haichao Wei, Jia Qian Wu   +2 more
doaj   +1 more source

Continual learning approaches for single cell RNA sequencing data

Scientific Reports, 2023
Single-cell RNA sequencing data is among the most interesting and impactful data of today and the sizes of the available datasets are increasing drastically.
Gorkem Saygili, Busra OzgodeYigin
doaj   +1 more source

Single-Cell RNA Sequencing: Opportunities and Challenges for Studies on Corneal Biology in Health and Disease

, 2023
The structure and major cell types of the multi-layer human cornea have been extensively studied. However, various cell states in specific cell types and key genes that define the cell states are not fully understood, hindering our comprehension of ...
Dulce Lima Cunha, Camille Laberthonnière, Julian A. Arts, Huiqing Zhou   +3 more
core   +1 more source

Bulk RNA-seq and scRNA-seq analysis reveal an activation of immune response and compromise of secretory function in major salivary glands of obese mice

Computational and Structural Biotechnology Journal, 2023
Obesity affects the function of multiple organs/tissues including the exocrine organ salivary glands. However, the effects of obesity on transcriptomes and cell compositions in the salivary glands have yet been studied by bulk RNA-sequencing and single ...
Heping Huang, Ce Gao, Shuai Wang, Fen Wu, Jinsong Wei, Jinrong Peng   +5 more
doaj   +1 more source

FEATS: feature selection-based clustering of single-cell RNA-seq data

, 2021
MOTIVATION: Advances in next-generation sequencing have made it possible to carry out transcriptomic studies at single-cell resolution and generate vast amounts of single-cell RNA sequencing (RNA-seq) data rapidly.
Vans, E, Patil, A, Sharma, A
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

CRISPR screening in single cells

, 2019
The combination of single-cell RNA-seq and CRISPR allows for efficient interrogation of possibly any number of genes, only limited by the sequencing capability. Here we describe the current protocols for CRISPR screening in single cells, from cloning and
Henriksson, Johan,
core   +1 more source

Deciphering Cell Lineage Specification during Male Sex Determination with Single-Cell RNA Sequencing [PDF]

, 2017
Summary: The gonad is a unique biological system for studying cell-fate decisions. However, major questions remain regarding the identity of somatic progenitor cells and the transcriptional events driving cell differentiation.
Emmanouil T. Dermitzakis, Serge Nef, Antonarakis, Stylianos E., Neirijnck, Yasmine, Nef, S, Yasmine Neirjinck, Isabelle Stévant, Neirijnck, Y, Jessica Escoffier, Stévant, I, Borel, Christelle, Dermitzakis, ET, Stévant, Isabelle, Nef, Serge, Smith, Lee B., Dermitzakis, Emmanouil T, Lee B. Smith, Escoffier Breancon, Jessica, Borel, C, Antonarakis, Stylianos, Stylianos E. Antonarakis, Antonarakis, SE, Dermitzakis, Emmanouil, Escoffier, J, Smith, LB, Christelle Borel, Smith, Lee B, Escoffier, Jessica, Yasmine Neirijnck   +28 more
core   +1 more source