Results 91 to 100 of about 5,522,894 (323)

Turing Instability in Reaction-Diffusion Systems with a Single Diffuser: Characterization Based on Root Locus

, 2013
Cooperative behaviors arising from bacterial cell-to-cell communication can be modeled by reaction-diffusion equations having only a single diffusible component.
Hara, Shinji, Hori, Yutaka, Miyazako, Hiroki   +2 more
core   +1 more source

A systematic overview of single-cell transcriptomics databases, their use cases, and limitations

Frontiers in Bioinformatics
Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies and experimental protocols have led to the generation of vast amounts of transcriptomic data that populates several online databases and repositories.
Mahnoor N. Gondal, Mahnoor N. Gondal, Saad Ur Rehman Shah, Arul M. Chinnaiyan, Arul M. Chinnaiyan, Arul M. Chinnaiyan, Arul M. Chinnaiyan, Arul M. Chinnaiyan, Arul M. Chinnaiyan, Marcin Cieslik, Marcin Cieslik, Marcin Cieslik, Marcin Cieslik   +12 more
doaj   +1 more source

A Quantitative Framework for Evaluating Single-Cell Data Structure Preservation by Dimensionality Reduction Techniques

Cell Reports, 2020
Summary: High-dimensional data, such as those generated by single-cell RNA sequencing (scRNA-seq), present challenges in interpretation and visualization.
Cody N. Heiser, Ken S. Lau
doaj   +1 more source

Single-cell analysis: toward the clinic [PDF]

Genome Medicine, 2013
Human life starts with a single cell, the zygote, which undergoes multiple mitotic cell divisions to form a complete body. During each cell division, the genome has to be replicated to form the approximately 1014 cells that make up the adult human body.
openaire   +3 more sources

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

A Universal Live Cell Barcoding-Platform for Multiplexed Human Single Cell Analysis. [PDF]

, 2018
Single-cell barcoding enables the combined processing and acquisition of multiple individual samples as one. This maximizes assay efficiency and eliminates technical variability in both sample preparation and analysis.
Bendall, Sean C, Hartmann, Felix J, Simonds, Erin F   +2 more
core  

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Microfluidics in Single Cell Analysis

, 2012
Microfluidics is a research field that evolved during the early 1980’s and is still under constant and rapid progress. As indicated by the name, microfluidics concerns the behaviour of fluids in micro length scale environments and originally has its roots in four different disciplines: molecular biology and analysis, microelectronics and, maybe a bit ...
Caroline Beck, Mattias Goksör
openaire   +3 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source