Results 91 to 100 of about 9,923,505 (317)
Nucleic Acids ResearchHundreds of millions of single cells have been analyzed using high-throughput transcriptomic methods. The cumulative knowledge within these datasets provides an exciting opportunity for unlocking insights into health and disease at the level of single ...
Shibla Abdulla +52 more
semanticscholar +1 more source
Cell Discovery, 2021 The current pathological and molecular classification of pancreatic ductal adenocarcinoma (PDAC) provides limited guidance for treatment options, especially for immunotherapy.
Yu Wang +19 more
semanticscholar +1 more source
Isolation, spectroscopic characterization, X-ray, theoretical studies as well as in vitro cytotoxicity of Samarcandin [PDF]
, 2016 Samarcandin 1, a natural sesquiterpene-coumarin, was isolated as well as elucidated from F. assa-foetida which has significant effect in Iranian traditional medicine because of its medicinal attitudes.
Atabaki, V. +7 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer.
Cancer Discovery, 2020 A subset of Cancer-Associated Fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers (BC), but its heterogeneity and its impact on immunotherapy response remain unknown.
Y. Kieffer +15 more
semanticscholar +1 more source
Science immunology, 2021 Integrated single-cell transcriptomic and BCR analyses reveal how antibody class switching influences human B cell fate and function. A human B cell roadmap B cells undergo affinity maturation and class switch recombination (CSR) within germinal centers (
Hamish W. King +6 more
semanticscholar +1 more source
Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. [PDF]
, 2019 Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to ...
Ahn, In Sook +15 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman +17 more
wiley +1 more source
Looking Back: Single-Cell Analysis [PDF]
Cell Stem Cell, 2017 Over the past few years, burgeoning single-cell analyses platforms have unlocked access to previously unobtainable biological information about stem cell populations. For our tenth anniversary, we asked authors that cited a selection of our most popular papers in this area about how these studies influenced their work and the field.
openaire +2 more sources
Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects. [PDF]
, 2019 Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific gene networks results in birth defects, which affect 5% of live births.
de Soysa, T Yvanka +9 more
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