Results 71 to 80 of about 32,538,527 (305)

On the mechanical interplay between intra- and inter-synchronization during collective cell migration : a numerical investigation [PDF]

, 2013
Collective cell migration is a fundamental process that takes place during several biological phenomena such as embryogenesis, immunity response, and tumorogenesis, but the mechanisms that regulate it are still unclear.
ALLENA, Rachele, Sharpe, J., AUBRY, Denis, SHARPE, James   +3 more
core   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages

, 2017
Stem cell engineering and grafting of mesencephalic dopamine (mesDA) neurons is a promising strategy for brain repair in Parkinson's disease (PD). Refinement of differentiation protocols to optimize this approach will require deeper understanding of ...
Perlmann, Thomas,, Storvall, Helena,, Gillberg, L, Perlmann, Thomas., Joodmardi, Eliza, Kirkeby, A, Gillberg, Linda,, Parmar, Malin,, Kirkeby, Agnete, Perlmann, Thomas, Lahti, Laura,, Sandberg, Rickard,, Nolbrant, Sara, Dahl, Lina,, Bjorklund, AK, Kee, N,, Storvall, H, Dahl, L, Kee, Nigel, Lahti, L, Björklund, Åsa K., Volakakis, Nikolaos, Kee, Nigel,, Dahl, Lina, Joodmardi, E, Parmar, Malin, Volakakis, N, Björklund, Åsa K.,, Bjoerklund, Aasa K., Joodmardi, Eliza,, Gillberg, Linda, Lahti, Laura, Storvall, Helena, Volakakis, Nikolaos,, Nolbrant, Sara,, Sandberg, Rickard, Nolbrant, S, Kirkeby, Agnete,   +37 more
core   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Laser-induced breakdown of an optically trapped gold nanoparticle for single cell transfection [PDF]

, 2013
The cell selective introduction of therapeutic agents remains a challenging problem. Here we demonstrate spatially controlled cavitation instigated by laser-induced breakdown of an optically trapped single gold nanoparticle of diameter 100 nm. The energy
Gunn-Moore, Frank J, Arita, Yoshihiko, Antkowiak, Maciej, Ploschner, Martin, Dholakia, Kishan, Yoshihiko Arita, Maciej Antkowiak, Frank Gunn-Moore, Gunn-Moore, Frank, Martin Ploschner, Kishan Dholakia   +10 more
core   +1 more source

Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis

Nature Communications, 2021
Application of human induced pluripotent stem cells (hiPSCs) for tissue regeneration is hindered by off-target cell differentiation. Here, the authors use bulk and single cell RNA-sequencing to identify WNT and MITF as off-target hubs during chondrogenic
Chia-Lung Wu, Amanda Dicks, Nancy Steward, Ruhang Tang, Dakota B. Katz, Yun-Rak Choi, Farshid Guilak   +6 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Current trends in single cell analysis [PDF]

Analytical and Bioanalytical Chemistry, 2014
Single cell analysis is a rapidly emerging research field that fascinates researchers from various disciplines: biologists, because it may reveal insights into fundamental aspects like evolution, cell adaptation, and cell differentiation; medical doctors and pharmacists, because it may have an impact in the understanding of diseases such as cancer, the
Dittrich P, Jakubowski N
openaire   +3 more sources

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

A comparison of integration methods for single‐cell RNA sequencing data and ATAC sequencing data

Quantitative Biology
Single‐cell genomics give us a new perspective to understand multivariate phenotypic and genetic effects at the cellular level. Recently, technologies have started measuring different modalities of individual cells, such as transcriptomes, epigenomes ...
Yulong Kan, Weihao Wang, Yunjing Qi, Zhongxiao Zhang, Xikeng Liang, Shuilin Jin   +5 more
doaj   +1 more source