Results 51 to 60 of about 32,538,527 (305)

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

Single-probe Single Cell Mass Spectrometry Studies: Investigation of Cell Heterogeneity and Quantification of Intracellular Small Molecules [PDF]

, 2023
Studying cell heterogeneity can provide a deeper understanding of biological activities, but corresponding studies cannot be performed using traditional bulk analysis methods.
Lan, Yunpeng
core  

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells [PDF]

, 2021
B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, by combining single-cell RNA and B
Greiff, Victor,, Borcherding, Nicholas, Bernasconi, Valentina, Lebrero-Fern\ue1ndez, Cristina, Smirnov, Ilya, Lebrero-Fernández, Cristina,, Mathew, Nimitha R.,, Schön, Karin,, Nakka, Sravya S.,, Jayanthan, Jayalal K., Yewdell, Jonathan W.,, Lebrero-Fernández, Cristina, Axelsson, Hannes, Yewdell, Jonathan W., Robinson, Jonathan, Rodin, William, Czarnewski, Paulo, Greiff, Victor, Angeletti, Davide,, Harandi, Ali M., Kalathilparambil Jayanthan, Jayalal, Rodin, William,, Robinson, Jonathan,, Bernasconi, V.,, Borcherding, Nicholas,, Axelsson, Hannes,, Lycke, Nils, Robinson, Jonathan L., Czarnewski, Paulo,, Angeletti, Davide, Sch\uf6n, Karin, Bernasconi, V., Smirnov, Ilya V., Smirnov, Ilya V.,, Lycke, N. Y.,, Yewdell, William T.,, Bemark, Mats, Nakka, Sravya S., Schön, Karin, Lycke, Nils Y., Yewdell, William T., Emmanouilidi, Aikaterini, Lycke, N. Y., Mathew, Nimitha R., Harandi, A. M., Bemark, Mats,, Harandi, A. M.,, Emmanouilidi, Aikaterini,, Jayanthan, Jayalal K.,   +48 more
core   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

DEVELOPMENT AND APPLICATION OF SINGLE CELL MASS SPECTROMETRY TECHNIQUES FOR NON-ADHERENT CELL ANALYSIS [PDF]

, 2020
Mass spectrometry (MS) analysis of biological samples is traditionally carried out using extractions from large populations of cells, concealing the information from individual cells.
Zhu, Yanlin
core  

Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner

The EMBO Journal
2-cell like cells (2CLC) are a transiently cycling population of cells with totipotent-associated features. Although CTCF depletion induces 2CLC conversion in mouse ESC, whether this reprogramming is a consequence of disrupted higher-order chromatin ...
Grace I Carey, Maria Vega-Sendino, Desiree Tillo, Sarah C Hoelscher, Amir Khan, Ian Taukulis, Teresa Olbrich, Bechara Saykali, Andy D Tran, Bhavya Soni, Anna Lee Fong, Melissa Mikolaj, Adam Harned, Kedar Narayan, Michael J Kruhlak, Michael Kelly, Ning Qing Liu, Elzo de Wit, Sergio Ruiz   +18 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Evaluating PSA dynamics for predicting androgen deprivation failure with a patient specific prostate cancer model

npj Systems Biology and Applications
Prostate cancer is the second leading cause of cancer-related death among American men, with a new diagnosis made every 2 min in the United States. Advanced cases are commonly treated with androgen deprivation therapy (ADT).
Shengchao Zhao, Evan T. Keller, Tyler Robinson, Jinlu Dai, Alyssa Ghose, Ajjai Alva, Trachette Jackson, Harsh Vardhan Jain   +7 more
doaj   +1 more source

scDC: single cell differential composition analysis

BMC Bioinformatics, 2019
Background Differences in cell-type composition across subjects and conditions often carry biological significance. Recent advancements in single cell sequencing technologies enable cell-types to be identified at the single cell level, and as a result ...
Yue Cao, Yingxin Lin, John T. Ormerod, Pengyi Yang, Jean Y.H. Yang, Kitty K. Lo   +5 more
doaj   +1 more source